FLNB
FLNB (filamin B, also known as TAP, TABP, ABP-278, FH1, FLN1L and LRS1) is a member of the filamin family that connects cell membrane constituents to the actin cytoskeleton. It also contributes to vascular injury repair through its interaction with glycoprotein Ib alpha. Browse Assay Genie's current range of FLNB research reagents below, or read on for the biology behind the target.
Filamin B links the cell membrane to the actin cytoskeleton. It anchors various transmembrane proteins to actin filaments, connects actin filaments to membrane glycoproteins, and may promote orthogonal branching of actin filaments. According to the NCBI Gene summary, the encoded protein interacts with glycoprotein Ib alpha during the repair of vascular injuries. The platelet glycoprotein Ib complex, which includes glycoprotein Ib alpha, binds the actin cytoskeleton.
The FLNB gene encodes a member of the filamin family, and the protein is annotated to the cytoplasm, where it is found at the cell cortex, in the cytoskeleton, on stress fibres and at the Z line of the sarcomere. Its interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Multiple alternatively spliced transcript variants encode different protein isoforms. Their varied interactions and localisations affect myotube morphology and myogenesis, and isoform 6 accelerates muscle differentiation in vitro. The mouse ortholog is Flnb.
FLNB was previously described as filamin B, beta (actin binding protein 278) and as Larsen syndrome 1 (autosomal dominant), the latter reflecting its disease associations. Mutations in the gene have been found in atelosteogenesis type 1 and type 3, boomerang dysplasia, autosomal dominant Larsen syndrome and spondylocarpotarsal synostosis syndrome. This makes the FLNB protein a frequent subject in studies of cytoskeletal organisation and skeletal development.
FLNB anchors transmembrane proteins to actin and may promote orthogonal branching of actin filaments, making it a key subject in membrane-cytoskeleton linkage.
Mutations in FLNB are found in atelosteogenesis, boomerang dysplasia, Larsen syndrome and spondylocarpotarsal synostosis syndrome.
Isoform-specific interactions and localisations of filamin B affect myotube morphology, and isoform 6 accelerates muscle differentiation in vitro.
FLNB interacts with FLNA in neuroblast migration and with glycoprotein Ib alpha in the repair of vascular injuries.
FLNB connects cell membrane constituents to the actin cytoskeleton. It anchors transmembrane proteins to actin, links actin filaments to membrane glycoproteins and may promote orthogonal branching of filaments. It also interacts with glycoprotein Ib alpha in vascular injury repair and, with FLNA, may support neuroblast migration.
FLNB is also known as filamin B, TAP, TABP, ABP-278, FH1, FLN1L and LRS1. Earlier names include filamin B, beta (actin binding protein 278) and Larsen syndrome 1 (autosomal dominant). Multiple alternatively spliced transcript variants encode different isoforms, including isoform 6, which accelerates muscle differentiation in vitro.
Mutations in the FLNB gene have been found in atelosteogenesis type 1 and type 3, boomerang dysplasia, autosomal dominant Larsen syndrome and spondylocarpotarsal synostosis syndrome. The mouse ortholog is Flnb; check the datasheet of any product for its validated reactivity.
Other filamin family members, actin-cytoskeleton partners and platelet glycoprotein Ib complex components.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75369; product specifications from Assay Genie datasheets.