FGF3
FGF3 (fibroblast growth factor 3, also known as HBGF-3 and INT2) is a secreted, heparin-binding member of the fibroblast growth factor family. It helps regulate embryonic development, cell proliferation and cell differentiation, and is required for normal ear development. Browse Assay Genie's current range of FGF3 research reagents below, or read on for the biology behind the target.
FGF3 is a secreted signalling protein that plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. It is required for normal ear development, and studies of the similar genes in mouse and chicken point to a role in inner ear formation. Like other members of the fibroblast growth factor (FGF) family, it is associated with broad mitogenic and cell survival activities, and with processes such as cell growth, morphogenesis and tissue repair.
The FGF3 gene encodes a protein of the heparin-binding growth factors family, and HGNC classifies it among receptor ligands within the fibroblast growth factor family. The mouse ortholog is Fgf3. Researchers working on this pathway may look for the FGF3 protein by its alias HBGF-3, or by the older gene name INT2, in the literature.
The INT2 name reflects the history of the gene. It was identified by its similarity to mouse Fgf3/int-2, a proto-oncogene activated in virally induced mammary tumours in the mouse, and its earlier HGNC name referred to the murine mammary tumour virus integration site (v-int-2) oncogene homolog. Frequent amplification of the FGF3 gene has been found in human tumours, which may be important for neoplastic transformation and tumour progression. This makes the target relevant to both developmental biology and cancer research, and to work on FGF family members in tumour growth and invasion.
FGF3 is required for normal ear development, and studies in mouse and chicken suggest a role in inner ear formation.
FGF3 helps regulate embryonic development, morphogenesis and cell differentiation, making it a useful target in developmental signalling studies.
Frequent amplification of the FGF3 gene in human tumours may contribute to neoplastic transformation and tumour progression.
As a heparin-binding FGF family ligand, FGF3 is studied for its roles in cell proliferation, survival and tissue repair.
FGF3 is a secreted growth factor that plays an important role in regulating embryonic development, cell proliferation and cell differentiation. It is required for normal ear development, and studies of similar genes in mouse and chicken suggest a role in inner ear formation.
FGF3 is also called HBGF-3 and INT2. The INT2 name comes from the mouse int-2 proto-oncogene, activated in virally induced mammary tumours, which the human gene was identified by similarity to. HGNC lists the full name as fibroblast growth factor 3.
Frequent amplification of the FGF3 gene has been found in human tumours, which may be important for neoplastic transformation and tumour progression. The mouse ortholog is Fgf3. Check the datasheet of any product for its validated reactivity.
Other fibroblast growth factors, FGF-binding proteins and FGF receptors relevant to developmental and tumour signalling research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11487; product specifications from Assay Genie datasheets.