SGK2
SGK2 (serum/glucocorticoid regulated kinase 2) is a serine/threonine protein kinase of the AGC kinase family. It regulates ion channels, membrane transporters and cell growth, survival and proliferation, and is related to SGK1 and SGK3. Browse Assay Genie's current range of SGK2 research reagents below, or read on for the biology behind the target.
SGK2 is a serine/threonine-protein kinase involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. It acts largely by up-regulating its targets. These include the sodium channel SCNN1A/ENAC, the potassium channels KCNA3/Kv1.3, KCNE1 and KCNQ1, the amino acid transporter SLC6A19, the glutamate transporter SLC1A6/EAAT4, the glutamate receptors GRIA1/GLUR1 and GRIK2/GLUR6, the Na(+)/H(+) exchanger SLC9A3/NHE3 and the Na(+)/K(+) ATPase. This breadth places the kinase at the interface between signalling and membrane transport.
The SGK2 protein belongs to the protein kinase superfamily and the AGC Ser/Thr protein kinase family, and is classed by HGNC in the serum/glucocorticoid regulated kinase family. It is found in the cytoplasm and the nucleus. The SGK2 gene encodes a catalytically active kinase (EC 2.7.11.1), and alternative splicing is reported to give rise to multiple transcript variants. Mouse and rat both carry an Sgk2 ortholog.
The name reflects its similarity to serum- and glucocorticoid-induced protein kinase (SGK, now SGK1). Unlike that kinase, however, the SGK2 gene is not induced by serum or glucocorticoids. It is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true of SGK1. HGNC also records the earlier name SGK2, serine/threonine kinase 2. These shared and distinct regulatory features make SGK2 a useful point of comparison when studying the wider SGK family.
SGK2 up-regulates channels including ENaC, Kv1.3, KCNE1 and KCNQ1, making it relevant to studies of how kinase signalling controls ion flux.
The kinase up-regulates transporters such as SLC6A19, EAAT4, NHE3 and the Na(+)/K(+) ATPase, supporting work on transport regulation.
SGK2 is induced in response to phosphatidylinositol 3-kinase activating signals, so it is a readout for this pathway.
SGK2 is involved in regulating cell growth, survival and proliferation, which makes it a candidate for studying these processes.
SGK2 is a serine/threonine kinase involved in regulating ion channels, membrane transporters, cell growth, survival and proliferation. It up-regulates targets including ENaC, Kv1.3, KCNQ1, SLC6A19, EAAT4, GLUR1, GLUR6, NHE3 and the Na(+)/K(+) ATPase. Check the datasheet of any product for its validated reactivity.
SGK2 is similar to serum- and glucocorticoid-induced protein kinase (SGK1), but its gene is not induced by serum or glucocorticoids. Like SGK1, it is induced in response to signals that activate phosphatidylinositol 3-kinase. SGK3 is a further member of the same family.
Yes. Mouse and rat each have an Sgk2 ortholog of the human gene. Alternative splicing of the human gene gives multiple transcript variants. Check the datasheet of any product for its validated reactivity before using it with a given species.
Other members of the serum/glucocorticoid regulated kinase family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HBY8; product specifications from Assay Genie datasheets.