CLEC6A
CLEC6A (C-type lectin domain containing 6A), also known as dectin-2, hDECTIN-2 and CLECSF10, is a calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. It recognises mannose-rich glycans on fungi and other pathogens. Browse Assay Genie's current range of CLEC6A research reagents below, or read on for the biology behind the target.
CLEC6A is a calcium-dependent lectin that functions as a pattern recognition receptor (PRR). It specifically recognises and binds alpha-mannans on Candida albicans hyphae. Binding leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, which triggers activation of SYK, CARD9 and NF-kappa-B. This signalling drives maturation of antigen-presenting cells and shapes antigen-specific priming of T cells towards effector T-helper 1 and T-helper 17 subtypes. NCBI describes signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines.
The CLEC6A protein is a type II membrane receptor with an extracellular C-type lectin-like domain fold, and it is located at the cell membrane. The extracellular portion binds structures with a high mannose content. It has been shown to recognise several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans and house dust mite. In a mannose-dependent manner it also recognises allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production, and it recognises soluble elements from the eggs of Schistosoma mansoni, altering adaptive immune responses.
The CLEC6A gene belongs to the HGNC groups for C-type lectin domain containing genes and the Dectin 2 cluster. Previous names include C-type lectin domain family 6, member A, and C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10. Two transcript variants encoding different isoforms have been reported. Mouse Clec6a and rat CLEC6A orthologs are recorded.
CLEC6A recognises alpha-mannans on C. albicans hyphae, making it a key receptor for studying how innate cells detect fungal pathogens.
CLEC6A recognises house dust mite and fungal allergens in a mannose-dependent manner and promotes cysteinyl leukotriene production.
Signalling through SYK, CARD9 and NF-kappa-B shapes antigen-specific T-cell priming towards T-helper 1 and T-helper 17 subtypes.
The receptor binds high-mannose structures on several pathogens, including M. tuberculosis and C. neoformans, and on S. mansoni egg components.
CLEC6A is a calcium-dependent pattern recognition receptor that binds mannose-rich structures, notably alpha-mannans on C. albicans hyphae. Ligand binding triggers FCER1G ITAM phosphorylation and activation of SYK, CARD9 and NF-kappa-B, leading to cytokine induction and T-helper 1 and T-helper 17 responses.
Yes. Dectin-2 and hDECTIN-2 are aliases of CLEC6A, and CLECSF10 is a previous symbol, from the older name C-type lectin superfamily member 10. HGNC places the gene in the Dectin 2 cluster. Two transcript variants encoding different isoforms have been described.
Orthologs are recorded in mouse (Clec6a) and rat (CLEC6A), which supports comparative work on antifungal and allergic responses. Reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Other C-type lectin receptors and innate immune pattern recognition targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6EIG7; product specifications from Assay Genie datasheets.