SNCG
SNCG (synuclein gamma, also known as gamma-synuclein, BCSG1, SR and persyn) is a member of the synuclein family. It contributes to neurofilament network integrity and has been linked to neurodegenerative disease and breast tumour development. Browse Assay Genie's current range of SNCG research reagents below, or read on for the biology behind the target.
SNCG plays a role in neurofilament network integrity and may be involved in modulating axonal architecture, both during development and in the adult. In vitro, it increases the susceptibility of neurofilament-H to calcium-dependent proteases. UniProt also reports that it may modulate the keratin network in skin, and that it activates the MAPK and Elk-1 signal transduction pathway.
The SNCG gene encodes gamma-synuclein, which belongs to the synuclein family. In UniProt, the protein is annotated in the perinuclear region of the cytoplasm and in the cytoskeleton, at the centrosome (a microtubule organising centre) and the spindle. Mouse and rat both carry an ortholog named Sncg, so the gene can be studied in common rodent models.
The protein is known by several names, including BCSG1 (breast cancer-specific gene 1 in common usage), SR and persyn. According to the NCBI Gene summary, synuclein family proteins are believed to be involved in the pathogenesis of neurodegenerative diseases, and mutations in this gene have also been associated with breast tumour development. This combination of cytoskeletal, neuronal and tumour-related associations makes SNCG a useful subject for research into both neurobiology and cancer. Researchers studying the SNCG gene or SNCG protein often examine its cytoskeletal roles and its effect on MAPK signalling.
Synuclein family proteins are believed to be involved in the pathogenesis of neurodegenerative diseases, so SNCG is studied in that context.
SNCG supports neurofilament network integrity and may modulate axonal architecture during development and in the adult.
Mutations in the SNCG gene have been associated with breast tumour development, making it relevant to cancer research.
SNCG activates the MAPK and Elk-1 signal transduction pathway, providing a route to study this signalling axis.
SNCG plays a role in neurofilament network integrity and may modulate axonal architecture during development and in the adult. It may also modulate the keratin network in skin, and it activates the MAPK and Elk-1 signal transduction pathway, according to UniProt.
SNCG stands for synuclein gamma, and the protein is called gamma-synuclein. Aliases and previous symbols include BCSG1, SR and persyn. It is classed by HGNC in the synuclein family, alongside related synuclein proteins.
Mouse and rat both have an ortholog called Sncg. NCBI Gene notes that synuclein family proteins are believed to be involved in neurodegenerative disease, and that mutations in SNCG have been associated with breast tumour development. Check the datasheet of any product for its validated reactivity.
Other synuclein family members, neurofilament components and MAPK pathway proteins studied alongside SNCG.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O76070; product specifications from Assay Genie datasheets.