NADK
NADK (NAD kinase, also known as NADK1 and FLJ13052) is the enzyme that phosphorylates NAD to produce NADP. It belongs to the NAD kinase family and supplies the NADP pool used in reductive biosynthesis. Browse Assay Genie's current range of NADK research reagents below, or read on for the biology behind the target.
NADK catalyses the transfer of a phosphate group from ATP to NAD, generating NADP. In its reduced form, NADP acts as an electron donor for biosynthetic reactions, so the reaction catalysed by NADK is a point of entry into the NADP-dependent side of cellular metabolism. This activity was described in work by Lerner and colleagues in 2001.
The NADK gene encodes a protein that belongs to the NAD kinase family and is classified by HGNC in the gene group of NAD kinases. The enzyme is assigned EC 2.7.1.23. The gene is also listed under the aliases NADK1 and FLJ13052, which may appear in older literature and database records. The mouse ortholog is Nadk, which allows the enzyme to be studied in murine systems.
Researchers working on NADK commonly study it in the context of NAD and NADP metabolism and reductive biosynthesis. When selecting an NADK antibody, NADK ELISA kit or NADK protein for an experiment, it is worth confirming the species and application against the product datasheet, since these details depend on the individual reagent.
NADK converts NAD to NADP using ATP, making it a central enzyme for studying how cells generate the NADP pool.
Reduced NADP serves as an electron donor, so NADK is relevant to research on the balance of nicotinamide cofactors.
NADP produced by NADK supports electron donation in biosynthetic reactions, linking the enzyme to anabolic pathway studies.
As a member of the NAD kinase family, NADK is a reference point for comparing NAD kinase activity and regulation.
NADK catalyses the transfer of a phosphate group from ATP to NAD to generate NADP. In its reduced form, NADP acts as an electron donor for biosynthetic reactions. The enzyme is classified as EC 2.7.1.23 and belongs to the NAD kinase family.
NADK is the approved HGNC symbol for NAD kinase. The gene is also known as NADK1 and FLJ13052. HGNC lists no previous names for it, but the aliases may appear in older papers and database entries, so searching all of them is useful.
A mouse ortholog, Nadk, is recorded for the human gene, so the enzyme can be studied in mouse models. Check the datasheet of any product for its validated reactivity before using it with a particular species.
Other NAD and NADP metabolism enzymes and related metabolic targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95544; product specifications from Assay Genie datasheets.