NPR1
NPR1 (natriuretic peptide receptor 1, also known as GUCY2A, ANPa, ANPRA and NPRA) is a membrane-bound guanylate cyclase that acts as the receptor for atrial and brain natriuretic peptides. On activation it produces cGMP, which supports cardiovascular homeostasis. Browse Assay Genie's current range of NPR1 research reagents below, or read on for the biology behind the target.
NPR1 is the receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP, two potent vasoactive hormones with a key role in cardiovascular homeostasis. When ANP or BNP activates the receptor, it stimulates production of cyclic guanosine monophosphate (cGMP). cGMP promotes vascular tone and volume homeostasis through activation of protein kinase cGMP-dependent 1 (PRKG1) and, subsequently, PRKAA1, so controlling blood pressure. NPR1 also plays an essential role in the regulation of endothelial cell senescence and vascular ageing.
The NPR1 gene encodes a member of the membrane guanylyl cyclases, often termed guanylyl cyclases A through F. These cell-surface receptors share a similar topology: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region containing a protein kinase-like domain and a cyclase catalytic domain. Guanylyl cyclases catalyse the production of cGMP from GTP. NPR1 belongs to the adenylyl cyclase class-4/guanylyl cyclase family and sits in the HGNC group of transmembrane guanylate cyclases.
NPR1 is also called guanylyl cyclase A (GC-A) and was formerly named atrionatriuretic peptide receptor A or natriuretic peptide receptor A. Together with NPR2 (GC-B), it functions as a natriuretic peptide receptor. NPR3 is a related gene whose product has only the ligand-binding transmembrane region and a 37-amino acid cytoplasmic domain, so it lacks the kinase-like and cyclase domains found in NPR1. Mouse and rat both carry an Npr1 ortholog, which makes rodent models relevant to NPR1 research.
NPR1 mediates ANP and BNP signalling that supports vascular tone, volume homeostasis and blood pressure control.
NPR1 plays an essential role in regulating endothelial cell senescence and vascular ageing.
Ligand-activated NPR1 produces cGMP, which activates PRKG1 and subsequently PRKAA1, making it a model for membrane guanylate cyclase signalling.
NPR1 is a receptor for both ANP and BNP, and is studied alongside NPR2 and NPR3 in natriuretic peptide pathways.
NPR1 is the receptor for ANP and BNP. When either peptide binds, NPR1 stimulates cGMP production, which activates PRKG1 and subsequently PRKAA1. This promotes vascular tone and volume homeostasis, so controlling blood pressure and supporting cardiovascular homeostasis.
NPR1 is also known as GUCY2A, ANPa, ANPRA, NPRA and guanylyl cyclase A (GC-A). Earlier names were atrionatriuretic peptide receptor A and natriuretic peptide receptor A. UniProt lists the protein as atrial natriuretic peptide receptor 1.
Mouse and rat each have an Npr1 ortholog. Within the family, NPR1 and NPR2 are both natriuretic peptide receptors, while NPR3 has only the ligand-binding transmembrane region and a short cytoplasmic domain. Check the datasheet of any product for its validated reactivity.
Other natriuretic peptide receptors in the same family, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P16066; product specifications from Assay Genie datasheets.