SALL2
SALL2 (spalt like transcription factor 2, also known as Sal-like protein 2, Hsal2, KIAA0360 and ZNF795) is a probable nuclear transcription factor of the sal C2H2-type zinc-finger family. It has a role in eye development, including closure of the optic fissure. Browse Assay Genie's current range of SALL2 research reagents below, or read on for the biology behind the target.
SALL2 is a probable transcription factor that plays a role in eye development before, during and after optic fissure closure. The optic fissure is a structure of the embryonic eye, and its closure is a necessary step in forming the mature organ. As a nuclear protein, SALL2 is thought to act by regulating gene expression, which fits its classification as a transcription factor.
The SALL2 gene encodes a protein containing multiple zinc finger domains. It belongs to the sal C2H2-type zinc-finger protein family and is classified by HGNC within the C2H2-type zinc finger gene group. Researchers studying the SALL2 protein therefore work with a member of a family defined by its zinc-finger DNA-binding architecture. Another family member, SALL4, is a useful point of comparison when examining how sal-like factors differ in function. The mouse ortholog is Sall2.
The gene has carried several names. Alongside SALL2, the literature refers to Hsal2, KIAA0360 and ZNF795, and earlier HGNC names were sal (Drosophila)-like 2 and sal-like 2 (Drosophila), reflecting its relationship to the Drosophila spalt gene. Mutations in the SALL2 gene are associated with ocular coloboma, a developmental eye condition, which links the factor directly to the optical fissure closure role described in the embryo. This makes SALL2 a relevant target for work on ocular development and congenital eye malformation.
SALL2 acts in eye development before, during and after optic fissure closure, making it a focus for studies of embryonic ocular morphogenesis.
Mutations in the SALL2 gene are associated with ocular coloboma, so the protein is relevant to studies of this congenital eye condition.
SALL2 is a probable transcription factor with multiple zinc finger domains, useful for studying nuclear gene regulation by sal-like proteins.
As a sal C2H2-type zinc-finger protein, SALL2 allows comparison of the roles of related family members such as SALL4.
SALL2 is a probable transcription factor that plays a role in eye development before, during and after optic fissure closure. NCBI Gene summarises its function as optical fissure closure during embryonic eye development. It is a nuclear protein containing multiple zinc finger domains.
SALL2 is also called Sal-like protein 2, Hsal2, KIAA0360 and ZNF795. Its previous HGNC names were sal (Drosophila)-like 2 and sal-like 2 (Drosophila). The official full name is spalt like transcription factor 2.
Mutations in the SALL2 gene are associated with ocular coloboma. A mouse ortholog, Sall2, exists, and the name reflects homology to Drosophila spalt. Check the datasheet of any product for its validated reactivity.
Other sal-like zinc-finger transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y467; product specifications from Assay Genie datasheets.