GAS2
GAS2 (growth arrest specific 2) is a member of the GAS2 family and a caspase-3 substrate that helps regulate microfilament organisation and cell shape during apoptosis. It also maintains microtubule bundles in the supporting cells of the inner ear. Browse Assay Genie's current range of GAS2 research reagents below, or read on for the biology behind the target.
GAS2 is a cytoskeleton-associated protein with roles in both apoptosis and tissue mechanics. According to the NCBI Gene summary, it is a substrate of caspase-3 and contributes to the regulation of microfilament and cell shape changes during apoptosis. It can also modulate how susceptible cells are to p53-dependent apoptosis, which it does by inhibiting calpain activity. This places the GAS2 protein at a point where cytoskeletal remodelling meets cell-death signalling.
A second, structural function is described in UniProt. GAS2 is required to maintain microtubule bundles in the supporting cells of the inner ear. These bundles give the cells the mechanical stiffness needed to transmit sound energy through the cochlea. In cells, the protein is annotated to the cytoplasm, where it is found on stress fibres, and to the membrane.
The GAS2 gene (HGNC symbol GAS2, full name growth arrest specific 2) encodes Growth arrest-specific protein 2, which belongs to the GAS2 family. Alternative splicing of the gene produces multiple transcript variants. The mouse ortholog is Gas2. Related genes with similar names, such as GAS1, GAS6 and GAS8, are separate genes and should not be confused with GAS2 when designing experiments.
GAS2 is a caspase-3 substrate involved in microfilament and cell shape changes during apoptosis, making it relevant to studies of cell-death morphology.
GAS2 can modulate susceptibility to p53-dependent apoptosis by inhibiting calpain activity, linking it to apoptotic control mechanisms.
The protein is annotated to stress fibres in the cytoskeleton, supporting work on microfilament organisation and cell shape.
GAS2 maintains microtubule bundles in inner ear supporting cells, which provide the stiffness needed to transmit sound energy through the cochlea.
GAS2 is a caspase-3 substrate that helps regulate microfilament and cell shape changes during apoptosis. It can also modulate susceptibility to p53-dependent apoptosis by inhibiting calpain. In the inner ear, it maintains microtubule bundles in supporting cells, giving them mechanical stiffness for sound transmission through the cochlea.
The HGNC-approved symbol is GAS2 and the full name is growth arrest specific 2. UniProt lists the protein name as Growth arrest-specific protein 2. No other aliases are recorded in the data. NCBI Gene notes that alternative splicing gives multiple transcript variants.
A mouse ortholog, Gas2, is recorded for the human gene. GAS2 belongs to the GAS2 family, which is distinct from other genes with similar names such as GAS1, GAS6 and GAS8. Check the datasheet of any product for its validated reactivity.
Other growth arrest-specific genes and related proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43903; product specifications from Assay Genie datasheets.