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Anti-GAS2 Antibody (CAB1168)

SKU:
CAB1168
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-GAS2 Antibody CAB1168
  • Cell Death Antibodies 1 Anti-GAS2 Antibody CAB1168
  • Cell Death Antibodies 1 Anti-GAS2 Antibody CAB1168
€139 - €419
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Description

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Antibody Name:Anti-GAS2 Antibody
Antibody SKU:CAB1168
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human GAS2 (NP_005247.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:SW620, Mouse liver, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human GAS2 (NP_005247.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MCTA LSPK VRSG PGLS DMHQ YSQW LASR HEAN LLPM KEDL ALWL TNLL GKEI TAET FMEK LDNG ALLC QLAE TMQE KFKE SMDA NKPT KNLP LKKI PCKT
Gene ID:2620
Uniprot:O43903
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein, cytoskeleton
Calculated MW:15kDa/34kDa
Observed MW:37kDa
Synonyms:GAS2, GAS-2
Background:The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:GAS2: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process. Belongs to the GAS2 family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Apoptosis

Chromosomal Location of Human Ortholog: 11p14.3

Cellular Component: membrane; actin filament; cytosol

Biological Process: regulation of cell shape; apoptosis; cell cycle arrest; cell structure disassembly during apoptosis

NCBI Summary:The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
UniProt Code:O43903
NCBI GenInfo Identifier:3913719
NCBI Gene ID:2620
NCBI Accession:O43903.1
UniProt Secondary Accession:O43903,Q6ICV8, Q7Z3X8, B2R9C8, D3DQZ0,
UniProt Related Accession:O43903
Molecular Weight:313
NCBI Full Name:Growth arrest-specific protein 2
NCBI Synonym Full Names:growth arrest-specific 2
NCBI Official Symbol:GAS2  
NCBI Protein Information:growth arrest-specific protein 2; GAS-2
UniProt Protein Name:Growth arrest-specific protein 2
Protein Family:GAS2-like protein
UniProt Gene Name:GAS2  
UniProt Entry Name:GAS2_HUMAN
Anti-GAS2 Antibody (CAB1168)Western blot analysis of extracts of various cell lines, using GAS2 antibody (CAB1168) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-GAS2 Antibody (CAB1168)Immunohistochemistry of paraffin-embedded human liver cancer using GAS2 antibody (CAB1168) at dilution of 1:200 (40x lens).
Anti-GAS2 Antibody (CAB1168)Immunofluorescence analysis of HeLa cells using GAS2 antibody (CAB1168). Blue: DAPI for nuclear staining.

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