SDC2
SDC2 (syndecan 2, also known as fibroglycan, SYND2, CD362, HSPG and HSPG1) is a transmembrane heparan sulfate proteoglycan of the syndecan family. It acts at the cell surface to regulate dendritic arbor morphogenesis and to mediate cell–matrix interactions. Browse Assay Genie's current range of SDC2 research reagents below, or read on for the biology behind the target.
SDC2 is a cell surface proteoglycan that regulates dendritic arbor morphogenesis. It is a type I transmembrane heparan sulfate proteoglycan, and it functions as an integral membrane protein. Through its role as a receptor for extracellular matrix proteins, syndecan-2 participates in cell proliferation, cell migration and cell–matrix interactions. Researchers studying the SDC2 protein therefore often work on adhesion, motility and the way cells sense their surroundings.
SDC2 belongs to the syndecan proteoglycan family, a group of proteins that mediate cell binding, cell signalling and cytoskeletal organisation. Syndecan receptors are also required for the internalisation of the HIV-1 tat protein, which links this family to viral protein uptake. In the HGNC classification the SDC2 gene sits within both the syndecan group and the CD molecules, and the protein is designated CD362. The mouse and rat orthologues are both named Sdc2, which allows the same target to be followed in common rodent models.
The gene was formerly named heparan sulfate proteoglycan 1, cell surface-associated, which explains the aliases HSPG and HSPG1 found in older literature; fibroglycan and SYND2 are further names for the same protein. Altered syndecan-2 expression has been detected in several different tumour types, making SDC2 a recurring subject in cancer biology alongside its established roles in cell signalling and neuronal morphology.
SDC2 regulates dendritic arbor morphogenesis, making it a relevant target for studies of how neurons shape their dendritic structure.
Syndecan-2 acts as a receptor for extracellular matrix proteins and takes part in cell–matrix interactions.
SDC2 participates in cell proliferation and cell migration, two processes central to development, tissue repair and disease.
Altered syndecan-2 expression has been detected in several tumour types, supporting investigation of SDC2 in cancer research.
SDC2 is a cell surface heparan sulfate proteoglycan that regulates dendritic arbor morphogenesis. It also mediates cell binding, cell signalling and cytoskeletal organisation, and takes part in cell proliferation, migration and cell–matrix interactions as a receptor for extracellular matrix proteins.
SDC2 stands for syndecan 2. Aliases include fibroglycan, SYND2, CD362, HSPG and HSPG1, and the gene was previously named heparan sulfate proteoglycan 1, cell surface-associated. Check the datasheet of any product for its validated reactivity and the name it uses.
Altered syndecan-2 expression has been detected in several different tumour types. The gene has orthologues named Sdc2 in both mouse and rat, so it can be studied in rodent models; check the datasheet of any product for its validated reactivity.
Other syndecan family members and the syndecan-binding protein syntenin, relevant to proteoglycan signalling research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P34741; product specifications from Assay Genie datasheets.