Anti-SDC2 Antibody (CAB1810)

Antibody Name:	Anti-SDC2 Antibody
Antibody SKU:	CAB1810
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 19-144 of human SDC2 (NP_002989.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse
Positive Samples:	HeLa

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 19-144 of human SDC2 (NP_002989.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	ESRA ELTS DKDM YLDN SSIE EASG VYPI DDDD YASA SGSG ADED VESP ELTT SRPL PKIL LTSA APKV ETTT LNIQ NKIP AQTK SPEE TDKE KVHL SDSE RKMD PAEE DTNV YTEK HSDS LFKR TE
Gene ID:	6383
Uniprot:	P34741
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	22kDa
Observed MW:	50kDa

Synonyms:

SDC2, CD362, HSPG, HSPG1, SYND2

Background:

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.

UniProt Protein Function:	syndecan-2: a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Preferentially expressed in cells of mesenchymal origin. Is tyrosine phosphorylated and forms a complex with EphB2 in mouse brain. Plays a role in mediating adhesion and proliferation of colon carcinoma cells.
UniProt Protein Details:	Protein type:Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 8q22-q23 Cellular Component: lysosomal lumen; cell soma; Golgi lumen; integral to membrane; plasma membrane; synapse Molecular Function:protein binding; PDZ domain binding Biological Process: axon guidance; phototransduction, visible light; extracellular matrix organization and biogenesis; wound healing; glycosaminoglycan metabolic process; dendrite morphogenesis; regulation of dendrite morphogenesis; pathogenesis; response to caffeine; chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; carbohydrate metabolic process; ephrin receptor signaling pathway; response to hypoxia; retinoid metabolic process
NCBI Summary:	The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
UniProt Code:	P34741
NCBI GenInfo Identifier:	158962336
NCBI Gene ID:	6383
NCBI Accession:	P34741.2
UniProt Related Accession:	P34741
Molecular Weight:
NCBI Full Name:	Syndecan-2
NCBI Synonym Full Names:	syndecan 2
NCBI Official Symbol:	SDC2
NCBI Official Synonym Symbols:	HSPG; CD362; HSPG1; SYND2
NCBI Protein Information:	syndecan-2
UniProt Protein Name:	Syndecan-2
UniProt Synonym Protein Names:	Fibroglycan; Heparan sulfate proteoglycan core protein; HSPG; CD_antigen: CD362
Protein Family:	Syndecan
UniProt Gene Name:	SDC2
UniProt Entry Name:	SDC2_HUMAN

	Western blot analysis of extracts of HeLa cells, using SDC2 antibody (CAB1810) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
	Immunohistochemistry of paraffin-embedded mouse lung using SDC2 antibody (CAB1810) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human liver damage using SDC2 antibody (CAB1810) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human esophagus using SDC2 antibody (CAB1810) at dilution of 1:100 (40x lens).

Antibodies	ELISA Kits
Anti-SDC2 Antibody (CAB12500)	Human HSPG (Heparan Sulfate Proteoglycan) CLIA Kit (HUES00303)
SDC2 Antibody (PACO05001)	Human HSPG (Heparan Sulfate Proteoglycan) ELISA Kit (HUES01634)
	Human Syndecan-2 (SDC2) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)