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Anti-SRSF10 Antibody (CAB6024)

SKU:
CAB6024
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SRSF10
FUSIP1
FUSIP2
NSSR
PPP1R149
SFRS13
SFRS13A
SRp38
SRrp40
TASR
TASR1
TASR2
€139 - €419
Frequently bought together:

Description

Product Name:SRSF10 Rabbit pAb
Product Code:CAB6024
Size:50uL, 100uL
Synonyms:SRSF10, FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human SRSF10.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 22Rv1, K-562, C2C12, Mouse testis, Rat testis
Immunogen:Recombinant protein of human SRSF10.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10772
Uniprot:O75494
Cellular Location:Cytoplasm, Nucleus speckle
Calculated MW:20kDa/21kDa/22kDa/31kDa
Observed MW:40KDa
UniProt Protein Function:SRSF10: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. Belongs to the splicing factor SR family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: nuclear speck; nucleoplasm; nucleus Molecular Function: protein binding; RNA binding Biological Process: mRNA splice site selection; negative regulation of nuclear mRNA splicing, via spliceosome; nuclear mRNA splicing, via spliceosome; regulation of nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions
UniProt Protein Details:
NCBI Summary:This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Code:O75494
NCBI GenInfo Identifier:47605579
NCBI Gene ID:10772
NCBI Accession:O75494.1
UniProt Secondary Accession:O75494,O60572, Q5JRH9, Q5JRI0, Q5JRI2, Q5JRI3, Q5JRI4 Q96G09, A6NFM6, A6NI42
UniProt Related Accession:O75494
Molecular Weight:22,135 Da
NCBI Full Name:Serine/arginine-rich splicing factor 10
NCBI Synonym Full Names:serine and arginine rich splicing factor 10
NCBI Official Symbol:SRSF10  
NCBI Official Synonym Symbols:NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; PPP1R149  
NCBI Protein Information:serine/arginine-rich splicing factor 10
UniProt Protein Name:Serine/arginine-rich splicing factor 10
UniProt Synonym Protein Names:40 kDa SR-repressor protein; SRrp40; FUS-interacting serine-arginine-rich protein 1; Splicing factor SRp38; Splicing factor, arginine/serine-rich 13A; TLS-associated protein with Ser-Arg repeats; TASR; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated SR protein
Protein Family:Serine/arginine-rich splicing factor
UniProt Gene Name:SRSF10  
UniProt Entry Name:SRS10_HUMAN

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