CCNB1
CCNB1 (cyclin B1, also known as CCNB) is a regulatory protein of the cyclin family that controls the G2/M transition of the cell cycle. It binds and activates the cyclin-dependent kinase CDK1/CDC2, and together they form the maturation-promoting factor. Browse Assay Genie's current range of CCNB1 research reagents below, or read on for the biology behind the target.
CCNB1 is essential for the control of the cell cycle at the G2/M transition, the point at which a cell commits to mitosis. The protein binds and activates the cyclin-dependent protein kinase CDK1, also called CDC2 or p34(cdc2). The resulting complex is known as the maturation-promoting factor (MPF). CCNB1 is necessary for proper control of the G2/M phase transition, so it is a central reference point in studies of mitotic entry.
The human CCNB1 gene encodes G2/mitotic-specific cyclin-B1, which belongs to the cyclin family and the Cyclin AB subfamily. HGNC places it in the Cyclins gene group. UniProt records the protein in the cytoplasm, the nucleus and the centrosome, which is a microtubule organising centre. Orthologous genes, named Ccnb1, are found in the mouse and the rat, which allows comparative work in common model organisms.
The gene symbol CCNB is a previous symbol for CCNB1 and still appears in older literature. NCBI Gene describes the encoded protein as a regulatory protein involved in mitosis. Researchers who study cell division, CDK1 activity or mitotic regulation use CCNB1 as a target. Another B-type cyclin, CCNB2, is often examined alongside it. Any CCNB1 antibody, CCNB1 ELISA kit or CCNB1 protein reagent should be matched to the species and application of your experiment.
CCNB1 is essential for control of the G2/M transition, so it is widely studied when mapping how cells progress from G2 into mitosis.
CCNB1 binds and activates CDK1/CDC2 to form the maturation-promoting factor, making it central to work on cyclin-dependent kinase regulation.
As a regulatory protein involved in mitosis, CCNB1 supports investigation of the mechanisms that govern entry into and control of cell division.
CCNB1 is found in the cytoplasm, nucleus and centrosome, which makes it a useful subject for studying where cell cycle regulators act.
CCNB1 is essential for control of the cell cycle at the G2/M transition. It binds and activates the cyclin-dependent kinase CDK1/CDC2, forming the maturation-promoting factor (MPF). This complex is necessary for proper control of the transition from G2 into mitosis.
The HGNC name is cyclin B1, and UniProt lists the protein as G2/mitotic-specific cyclin-B1. CCNB is an alias and previous symbol for the gene. The CDK1 partner is also called CDC2 or p34(cdc2), so older papers may use that name when describing MPF.
Yes. The mouse and rat both have an orthologous gene named Ccnb1, so the protein can be studied in common model organisms. Human CCNB1 belongs to the cyclin family, Cyclin AB subfamily. Please check the datasheet of any product for its validated reactivity.
Other B-type cyclins and cell cycle regulators with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P14635; product specifications from Assay Genie datasheets.