CCDC3
CCDC3 (coiled-coil domain containing 3, also known as DKFZp761F241) is a secreted protein that restrains TNF-induced inflammatory signalling in endothelial cells. It also promotes lipid accumulation in adipose cells. Browse Assay Genie's current range of CCDC3 research reagents below, or read on for the biology behind the target.
CCDC3 negatively regulates the pro-inflammatory response to TNF in endothelial cells (ECs). It does this by inhibiting TNF-induced NF-kappaB activation in these cells. This places the protein within the control of TNF-mediated signalling. NCBI Gene annotation likewise describes involvement in the negative regulation of the tumour necrosis factor-mediated signalling pathway, and in signal transduction more broadly.
CCDC3 also has a metabolic role. UniProt annotation records that it positively regulates lipid accumulation in adipose cells, and NCBI Gene lists involvement in the negative regulation of lipid metabolic process. Together, these annotations link the CCDC3 protein to both vascular inflammation and lipid handling.
UniProt (Q9BQI4) classifies CCDC3 as a secreted protein, and NCBI Gene reports localisation to the extracellular region and the endoplasmic reticulum. The CCDC3 gene is named for its predicted coiled-coil domain, and the symbol DKFZp761F241 is an alias. A mouse ortholog, Ccdc3, is annotated, which allows the protein to be studied in murine models.
CCDC3 inhibits TNF-induced NF-kappaB activation in endothelial cells, making it relevant to studies of pro-inflammatory responses in the endothelium.
Annotated as a negative regulator of TNF-mediated signalling, CCDC3 is a useful point of study for how this pathway is restrained.
CCDC3 positively regulates lipid accumulation in adipose cells, so it is relevant to research on fat cell lipid storage.
NCBI Gene links CCDC3 to negative regulation of lipid metabolic process, supporting its study in metabolic regulation.
CCDC3 negatively regulates the TNF-induced pro-inflammatory response in endothelial cells by inhibiting TNF-induced NF-kappaB activation. It also positively regulates lipid accumulation in adipose cells. It is a secreted protein, and check the datasheet of any product for its validated reactivity.
The HGNC-approved name is coiled-coil domain containing 3, and UniProt lists the protein as coiled-coil domain-containing protein 3. DKFZp761F241 is a recorded alias. The symbol refers to the predicted coiled-coil region in the protein.
A mouse ortholog, Ccdc3, is annotated, so the gene can be studied in mouse models of inflammation and lipid metabolism. Data on a rat ortholog were not available here. Check the datasheet of any product for its validated reactivity.
Other coiled-coil domain-containing proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BQI4; product specifications from Assay Genie datasheets.