STOM
STOM (stomatin) is an integral membrane protein of the band 7/mec-2 family that regulates ion channel activity and transmembrane ion transport. It is also known as BND7, EPB7 and EPB72, and was originally described as erythrocyte membrane protein band 7.2. Browse Assay Genie's current range of STOM research reagents below, or read on for the biology behind the target.
STOM is a regulator of ion channel activity and transmembrane ion transport. According to UniProt, it regulates the activity of the acid-sensing ion channels ASIC2 and ASIC3. The NCBI Gene summary describes the encoded protein as one that may regulate ion channels and transporters at the cell membrane.
The STOM gene encodes a member of a highly conserved family of integral membrane proteins, classed in HGNC as the stomatin family and in UniProt as part of the band 7/mec-2 family. The protein localises to the cell membrane of red blood cells and other cell types. UniProt also records it in the cytoplasmic cytoskeleton, membrane rafts, melanosomes and cytoplasmic vesicles. A pseudogene for this gene lies on chromosome 6, and alternative splicing produces multiple transcript variants. The mouse ortholog is Stom.
The protein was first named for its place in the red blood cell membrane, as erythrocyte membrane protein band 7.2 (stomatin), which explains the aliases BND7, EPB7 and EPB72. Loss of STOM localisation is associated with hereditary stomatocytosis, a form of haemolytic anaemia. This link makes the stomatin protein a useful subject for studies of red cell membrane biology and of how membrane proteins influence ion transport.
STOM regulates ion channel activity and transmembrane ion transport, including the acid-sensing channels ASIC2 and ASIC3, making it relevant to channel modulation studies.
The protein localises to the red blood cell membrane, where it is studied as a component of the erythrocyte membrane.
Loss of STOM localisation is associated with hereditary stomatocytosis, a form of haemolytic anaemia, supporting disease mechanism research.
STOM is found at the cell membrane, membrane rafts and cytoskeleton, so it features in work on membrane microdomains and trafficking.
STOM regulates ion channel activity and transmembrane ion transport. UniProt specifically notes that it regulates ASIC2 and ASIC3 channel activity. The NCBI Gene summary adds that it may regulate ion channels and transporters at the cell membrane of red blood cells and other cell types.
STOM is the HGNC symbol for stomatin. Aliases include BND7, EPB7 and EPB72, and the previous name was erythrocyte membrane protein band 7.2 (stomatin). Alternative splicing of the STOM gene gives rise to multiple transcript variants.
Loss of STOM localisation is associated with hereditary stomatocytosis, a form of haemolytic anaemia. The gene encodes a member of a highly conserved membrane protein family, and the mouse ortholog is Stom. Check the datasheet of any product for its validated reactivity.
Other stomatin family members and related membrane proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P27105; product specifications from Assay Genie datasheets.