CDH17
CDH17 (cadherin 17, also known as LI-cadherin, HPT-1 or cadherin) is a calcium-dependent cell adhesion protein of the cadherin superfamily. It is a component of the gastrointestinal tract and pancreatic ducts and is involved in intestinal peptide transport. Browse Assay Genie's current range of CDH17 research reagents below, or read on for the biology behind the target.
CDH17 is a member of the cadherin superfamily, a group of calcium-dependent, membrane-associated glycoproteins. Cadherins preferentially interact with themselves in a homophilic manner when connecting cells, and may therefore contribute to the sorting of heterogeneous cell types. LI-cadherin, as CDH17 is also called, may have a role in the morphological organization of the liver and intestine.
The CDH17 protein is cadherin-like: it has an extracellular region containing seven cadherin domains and a transmembrane region, but it lacks the conserved cytoplasmic domain found in classical cadherins. It localises to the cell membrane. It is a component of the gastrointestinal tract and pancreatic ducts, where it acts as an intestinal proton-dependent peptide transporter. This is the first step in the oral absorption of many medically important peptide-based drugs. Alternative splicing of the CDH17 gene results in multiple transcript variants.
HGNC places the gene in the 7D cadherins group and lists the previous name LI cadherin (liver-intestine), with HPT-1 as an alias. Mouse and rat both have a Cdh17 ortholog. Other cadherin genes, such as CDH16, CDH3 and CDH2, are useful points of comparison when studying adhesion in epithelial and other tissues.
CDH17 is a calcium-dependent adhesion protein that interacts homophilically, making it relevant to studies of how cadherins connect cells and sort cell types.
CDH17 acts as an intestinal proton-dependent peptide transporter, the first step in oral absorption of many peptide-based drugs.
As a component of the gastrointestinal tract and pancreatic ducts, CDH17 is studied in the context of epithelial organisation in these tissues.
LI-cadherin may play a role in the morphological organization of liver and intestine, supporting developmental and tissue architecture studies.
CDH17 is a calcium-dependent cell adhesion protein that interacts homophilically to connect cells. It may contribute to the morphological organization of liver and intestine, and it is involved in intestinal peptide transport as a proton-dependent peptide transporter.
CDH17 is the HGNC symbol for cadherin 17. It is also called LI-cadherin (liver-intestine cadherin), HPT-1 and cadherin. UniProt lists the protein as Cadherin-17. Alternative splicing gives rise to multiple transcript variants of the gene.
Yes. Both mouse and rat have a Cdh17 ortholog of the human gene. Human CDH17 belongs to the 7D cadherins gene group. For reactivity with a particular species, check the datasheet of any product for its validated reactivity.
Other cadherin family members and adhesion proteins with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q12864; product specifications from Assay Genie datasheets.