ABI1
ABI1 (abl interactor 1, also known as E3B1, ABI-1 and SSH3BP1) is an adaptor protein of the ABI family that links signalling complexes to actin remodelling. It interacts with Abelson tyrosine kinases and takes part in cytoskeletal reorganisation and EGFR signalling. Browse Assay Genie's current range of ABI1 research reagents below, or read on for the biology behind the target.
ABI1 is an adaptor protein that facilitates signal transduction as a component of several multiprotein complexes. It regulates actin polymerisation and cytoskeletal remodelling through interactions with the nonreceptor tyrosine kinases ABL1 and ABL2, and it may act in the negative regulation of cell growth and transformation. It may also contribute to EGF-induced Erk pathway activation and is involved in EGFR signalling. Together with EPS8 it participates in transducing signals from Ras to Rac: in vitro, a trimeric complex of ABI1, EPS8 and SOS1 shows Rac-specific guanine nucleotide exchange factor (GEF) activity, with ABI1 appearing to act as the adapter. ABI1 also regulates ABL1/c-Abl-mediated phosphorylation of ENAH, and recruits WASF1 to lamellipodia, where it seems to regulate WASF1 protein level. As a component of the WAVE2 complex it has a role in macropinocytosis.
The ABI1 protein is found in the cytoplasm and nucleus, and at the cytoskeleton, lamellipodia, filopodia, growth cones and the postsynaptic density. In brain, it seems to regulate dendritic outgrowth and branching and to determine the shape and number of synaptic contacts in developing neurons. The ABI1 gene belongs to the ABI family, which is classed with SH3 domain containing proteins, and produces multiple isoforms through alternative splicing. A pseudogene is located on the long arm of chromosome 14. Mouse and rat orthologues are both named Abi1.
ABI1 has also been known as spectrin SH3 domain binding protein 1 (SSH3BP1) and abl-interactor 1. The gene may play a role in the progression of several malignancies, including melanoma, colon cancer and breast cancer. A t(10;11) chromosomal translocation involving ABI1 and the MLL gene has been associated with acute myeloid leukaemia.
ABI1 regulates actin polymerisation and cytoskeletal remodelling, and recruits WASF1 to lamellipodia as part of the WAVE2 complex.
With EPS8 and SOS1, ABI1 forms a complex that mediates signal transduction from Ras to Rac.
ABI1 may play a role in the progression of melanoma, colon and breast cancer, and an ABI1-MLL translocation is linked to acute myeloid leukaemia.
In brain, ABI1 seems to regulate dendritic outgrowth and branching and the shape and number of synaptic contacts in developing neurons.
ABI1 is an adaptor protein that supports signal transduction in multiprotein complexes and regulates actin polymerisation and cytoskeletal remodelling. It interacts with ABL kinases, takes part in EGFR signalling, links Ras to Rac with EPS8 and SOS1, and recruits WASF1 to lamellipodia.
ABI1 is also called E3B1, ABI-1 and SSH3BP1. Earlier names include spectrin SH3 domain binding protein 1 and abl-interactor 1. Alternative splicing of the ABI1 gene produces multiple transcript variants that encode different isoforms, so check the datasheet of any product for its validated reactivity.
The ABI1 gene may play a role in the progression of melanoma, colon cancer and breast cancer. A t(10;11) translocation joining ABI1 and MLL has been associated with acute myeloid leukaemia. Mouse and rat both carry an orthologue named Abi1.
Other ABI family members, Abl kinases, Ras-Rac signalling partners and actin regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IZP0; product specifications from Assay Genie datasheets.