KRT13
KRT13 (keratin 13, also known as K13 or CK13) is a type I cytokeratin and a structural component of intermediate filaments in mucosal stratified squamous epithelia. It pairs with the type II keratin KRT4 to provide structural integrity to the epithelium. Browse Assay Genie's current range of KRT13 research reagents below, or read on for the biology behind the target.
KRT13 is a structural component of intermediate filaments in mucosal stratified squamous epithelia. It forms heteropolymers with the type II keratin KRT4, and these pairs assemble into keratin intermediate filament networks. The networks provide structural integrity and mechanical stability to the mucosal epithelium. KRT13 also contributes to postnatal tongue mucosal cell homeostasis and to tissue organisation in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2.
The KRT13 gene encodes a member of the keratin gene family. Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells, and are subdivided into cytokeratins and hair keratins. Most type I cytokeratins are acidic proteins arranged in pairs of heterotypic keratin chains. KRT13 is the type I partner of keratin 4 and is expressed in the suprabasal layers of non-cornified stratified epithelia. The protein belongs to the intermediate filament family and is classed by HGNC in the type I keratin group. Mouse and rat each have a Krt13 ortholog. Alternative splicing of the gene results in multiple transcript variants, although not all have been described.
The type I cytokeratin genes are clustered in a region of chromosome 17q21.2. Mutations in KRT13 and in keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The gene has also appeared in the literature under the names keratin 13, type I, K13 and CK13, as well as the older symbols MGC3781 and MGC161462.
KRT13 is a structural intermediate filament component of mucosal stratified squamous epithelia, making it relevant to studies of epithelial integrity and mechanical stability.
KRT13 forms heteropolymers with the type II keratin KRT4, offering a defined pair for studying keratin intermediate filament network assembly.
KRT13 is expressed in the suprabasal layers of non-cornified stratified epithelia, which links it to research on layer-specific epithelial organisation.
Mutations in KRT13 and KRT4 are associated with the autosomal dominant disorder White Sponge Nevus, making KRT13 relevant to inherited mucosal disease research.
KRT13 is a structural component of intermediate filaments in mucosal stratified squamous epithelia. With its type II partner KRT4 it assembles into keratin networks that give the epithelium structural integrity and mechanical stability. It also contributes to tongue mucosal homeostasis and tissue organisation under mechanical stress.
KRT13 is also called keratin 13, K13 and CK13, and its UniProt name is Keratin, type I cytoskeletal 13. Earlier symbols include MGC3781 and MGC161462, and the previous HGNC name was keratin 13, type I. Alternative splicing gives multiple transcript variants.
Mutations in KRT13 and keratin 4 are associated with the autosomal dominant disorder White Sponge Nevus. Mouse and rat both carry a Krt13 ortholog; check the datasheet of any product for its validated reactivity.
Other type I and type II keratins and intermediate filament proteins, including the KRT4 partner of KRT13, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P13646; product specifications from Assay Genie datasheets.