MUC20
MUC20 (mucin 20, cell surface associated) is a member of the mucin family of high molecular weight glycoproteins, also known as FLJ14408 or KIAA1359. Its C-terminus associates with MET and suppresses some downstream MET signalling cascades. Browse Assay Genie's current range of MUC20 research reagents below, or read on for the biology behind the target.
MUC20 is a mucin, a class of high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. Beyond this family role, MUC20 has a defined function in receptor tyrosine kinase signalling. Its C-terminus associates with the multifunctional docking site of the MET proto-oncogene, and it may regulate the MET signalling cascade. It appears to decrease transient MAPK activation induced by hepatocyte growth factor (HGF), and it blocks GRB2 recruitment to MET, which suppresses the GRB2-RAS pathway. It also inhibits HGF-induced proliferation and HGF-induced expression of MMP1 and MMP9.
UniProt records the mucin-20 protein as secreted and as present at the apical and basolateral cell membrane, including the microvillus membrane. The MUC20 gene sits at 3q29, and a related pseudogene is also found on chromosome 3. The protein carries a mucin tandem repeat domain, and the number of copies varies between two and six in most individuals. Multiple variants encoding different isoforms have been reported for the gene. The mouse ortholog is Muc20.
The gene is also listed under the aliases FLJ14408 and KIAA1359. Researchers studying MUC20 often do so in the context of MET signalling and epithelial mucin biology, and alongside other members of the HGNC mucin gene group.
MUC20 associates with the MET docking site and suppresses some downstream MET signalling cascades, making it a useful point of study for receptor regulation.
MUC20 appears to decrease HGF-induced transient MAPK activation and blocks GRB2 recruitment to MET, suppressing the GRB2-RAS pathway.
As a mucin, MUC20 belongs to a family of glycoproteins secreted by epithelial tissues to form a mucous barrier.
MUC20 inhibits HGF-induced proliferation and the induced expression of MMP1 and MMP9, linking it to downstream cellular responses of MET.
MUC20 is a mucin that may regulate MET signalling. It appears to reduce HGF-induced transient MAPK activation, blocks GRB2 recruitment to MET and so suppresses the GRB2-RAS pathway, and inhibits HGF-induced proliferation and MMP1 and MMP9 expression.
MUC20 stands for mucin 20, cell surface associated, and UniProt names the protein Mucin-20. Aliases are FLJ14408 and KIAA1359. Multiple variants encoding different isoforms have been found for the gene, so check which isoform is relevant to your work.
A mouse ortholog, Muc20, exists. In humans the mucin tandem repeat domain varies between two and six copies in most individuals. A related pseudogene is also located on chromosome 3. Check the datasheet of any product for its validated reactivity.
Other mucin family members with products at Assay Genie, useful for comparing epithelial mucin biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N307; product specifications from Assay Genie datasheets.