THOC1
THOC1 (THO complex subunit 1, also known as P84 and HPR1) is a subunit of the THO complex, which forms part of the transcription export (TREX) complex and is involved in mRNA export from the nucleus. The THOC1 gene has also been implicated in autosomal dominant nonsyndromic deafness 86. Browse Assay Genie's current range of THOC1 research reagents below, or read on for the biology behind the target.
THOC1 is a component of the THO complex, which is part of the transcription export complex, often referred to as the TREX complex. Its role is in mRNA export from the nucleus, moving transcripts from their site of synthesis to the cytoplasm. The NCBI Gene summary also records that the protein enables identical protein binding activity. In the context of infection, the TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and for infectious virus production.
The THOC1 protein belongs to the THOC1 family. It is found in several compartments: nuclear speckles, nucleoplasm and nuclear matrix, as well as the cytoplasm. NCBI Gene also reports it at the chromosome telomeric region. This spread of locations is consistent with a protein that works within the nucleus and in the handover of messenger RNA to the export machinery. Researchers studying the THOC1 protein often examine it alongside other THO and TREX components.
HGNC places THOC1 in the THO complex gene group. The approved name is THO complex subunit 1, and the previous name was THO complex 1. The aliases P84 and HPR1 still appear in the literature, so it is worth searching under all of them. In terms of disease relevance, the THOC1 gene is implicated in autosomal dominant nonsyndromic deafness 86. Mouse and rat each carry an orthologous gene, named Thoc1, which allows comparative work in rodent systems.
THOC1 participates in nuclear mRNA export as part of the THO complex, making it a relevant subunit for studying how transcripts reach the cytoplasm.
As part of the transcription export complex, THOC1 is studied alongside partner subunits to understand how the THO complex is organised.
The TREX complex is essential for export of KSHV intronless mRNAs and infectious virus production, linking THOC1-containing assemblies to viral replication.
THOC1 is implicated in autosomal dominant nonsyndromic deafness 86, so it is of interest in genetic studies of hearing impairment.
THOC1 is a subunit of the THO complex, which is part of the transcription export complex. It is involved in mRNA export from the nucleus. NCBI Gene also notes that it enables identical protein binding activity. Check the datasheet of any product for its validated reactivity.
THOC1 is the HGNC symbol for THO complex subunit 1. The aliases P84 and HPR1 are also used, and the previous name was THO complex 1. Searching under each name helps when reviewing older publications on this gene.
The THOC1 gene is implicated in autosomal dominant nonsyndromic deafness 86. Orthologues exist in mouse and rat, both named Thoc1, so rodent models can be used for comparative studies. The TREX complex is also required for KSHV intronless mRNA export.
Other THO complex subunits and TREX-associated mRNA export factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96FV9; product specifications from Assay Genie datasheets.