MAP9
MAP9 (microtubule associated protein 9, also known as ASAP) is a microtubule-associated protein involved in organising the bipolar mitotic spindle. It is required for spindle function, mitotic progression and cytokinesis. Browse Assay Genie's current range of MAP9 research reagents below, or read on for the biology behind the target.
MAP9 is a microtubule-associated protein that contributes to the organisation of the bipolar mitotic spindle. According to UniProt, it is required for bipolar spindle assembly, progression through mitosis and cytokinesis. It may also act by stabilising interphase microtubules, which suggests a role in the cytoskeleton outside of cell division as well as during it.
The MAP9 protein is annotated as cytoplasmic and cytoskeletal, with a specific localisation to the spindle. This fits its described role in spindle function. Researchers studying mitotic mechanics, microtubule stability or cytokinesis therefore use the MAP9 gene and its protein product as a defined point of study. The mouse ortholog is Map9.
The protein was characterised under the name ASAP, and the NCBI Gene summary describes it as a microtubule-associated protein required for spindle function, mitotic progression and cytokinesis, citing work by Saffin and colleagues in 2005. The earlier symbol FLJ21159 is also listed as a previous designation. The HGNC-approved name is microtubule associated protein 9. Because the name reads like others in the MAP series, take care to distinguish it from unrelated MAP kinase pathway genes that share a similar prefix.
MAP9 is involved in organising the bipolar mitotic spindle and is required for bipolar spindle assembly.
MAP9 is required for mitosis progression and cytokinesis, making it relevant to studies of how cells complete division.
MAP9 may act by stabilising interphase microtubules, a question of interest in cytoskeleton biology.
As a cytoplasmic microtubule-associated protein localised to the spindle, MAP9 is a useful subject for cytoskeletal research.
MAP9 is involved in organising the bipolar mitotic spindle. UniProt states that it is required for bipolar spindle assembly, mitosis progression and cytokinesis, and that it may act by stabilising interphase microtubules. It localises to the cytoplasm, cytoskeleton and spindle.
MAP9 is also known as ASAP, and FLJ21159 is a previous symbol. The HGNC full name is microtubule associated protein 9, and UniProt uses microtubule-associated protein 9. Check which name a publication uses when searching the literature.
A mouse ortholog, Map9, is recorded for the human gene. This allows mouse models to be used to study its role in spindle function and cell division. Check the datasheet of any product for its validated reactivity.
Other microtubule-associated proteins and similarly named MAP pathway targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q49MG5; product specifications from Assay Genie datasheets.