WNT2
WNT2 (Wnt family member 2, also known as IRP and INT1L1) is a secreted signalling protein of the Wnt family. It acts as a ligand for frizzled receptors and drives canonical Wnt signalling during embryonic development. Browse Assay Genie's current range of WNT2 research reagents below, or read on for the biology behind the target.
WNT2 is a ligand for members of the frizzled family of seven transmembrane receptors. It functions in the canonical Wnt signalling pathway, which results in activation of transcription factors of the TCF/LEF family. It also acts as an upstream regulator of FGF10 expression, linking Wnt signalling to a key growth factor pathway in tissue development.
The WNT2 protein is secreted and is found in the extracellular space and extracellular matrix. The WNT2 gene belongs to the WNT gene family, a group of structurally related genes that encode secreted signalling proteins. Alternatively spliced transcript variants have been identified for this gene. The mouse ortholog is Wnt2.
Functionally, WNT2 plays an important role in embryonic lung development. It may also contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons. Wnt family proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. The gene was previously named wingless-type MMTV integration site family member 2, and the aliases IRP and INT1L1 may appear in older literature.
WNT2 is a frizzled ligand that activates TCF/LEF transcription factors, making it a useful focus for studying canonical Wnt pathway activation.
WNT2 plays an important role in embryonic lung development and regulates FGF10 expression upstream, relevant to studies of lung morphogenesis.
WNT2 may contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons.
Wnt family proteins are implicated in oncogenesis and in cell fate and patterning during embryogenesis, placing WNT2 in cancer and developmental biology.
WNT2 is a secreted ligand for frizzled family receptors. It acts in the canonical Wnt pathway, leading to activation of TCF/LEF transcription factors, and regulates FGF10 expression upstream. It is important for embryonic lung development and may influence dopaminergic neuron proliferation in the developing brain.
The HGNC name is Wnt family member 2, and the UniProt protein name is Protein Wnt-2. Aliases and previous symbols include IRP and INT1L1, and the earlier name was wingless-type MMTV integration site family member 2. Alternatively spliced transcript variants have been identified for the gene.
The mouse ortholog is Wnt2. WNT2 belongs to the Wnt family, whose members are implicated in oncogenesis and in developmental processes such as cell fate and patterning. Check the datasheet of any product for its validated reactivity.
Other Wnt family ligands that signal through frizzled receptors and regulate development, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P09544; product specifications from Assay Genie datasheets.