ELOVL3
ELOVL3 (ELOVL fatty acid elongase 3, also known as CIG-30) is an endoplasmic reticulum-bound condensing enzyme that catalyses the first, rate-limiting step of the long-chain fatty acid elongation cycle. It extends long- and very long-chain fatty acids by two carbons per cycle. Browse Assay Genie's current range of ELOVL3 research reagents below, or read on for the biology behind the target.
ELOVL3 is the condensing enzyme of the endoplasmic reticulum-bound fatty acid elongation cycle, which comprises four reactions. It catalyses the first and rate-limiting of these, and each turn of the cycle adds two carbons to the chain of a long- or very long-chain fatty acid (VLCFA). The enzyme acts on both saturated and unsaturated acyl-CoA substrates, with the highest activity toward C18 acyl-CoAs, especially C18:0 acyl-CoA.
By extending these substrates, ELOVL3 may participate in producing saturated and monounsaturated VLCFAs of different chain lengths. These lipids are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. The NCBI Gene summary places the ELOVL3 gene in the GNS1/SUR4 family, whose members elongate long-chain fatty acids to provide precursors for the synthesis of sphingolipids and ceramides.
The protein is listed as very long chain fatty acid elongase 3 in UniProt and belongs to the ELO family, ELOVL3 subfamily. HGNC classifies it in the ELOVL fatty acid elongase family and records the previous name elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3, with CIG-30 as an alias. A mouse ortholog, Elovl3, is annotated. Researchers studying lipid elongation often examine ELOVL3 alongside other ELOVL enzymes such as ELOVL1.
ELOVL3 catalyses the rate-limiting condensation step of the elongation cycle, making it a focal point for studying how long-chain fatty acids are extended.
The enzyme may contribute to saturated and monounsaturated VLCFAs of varying chain lengths that serve in multiple biological processes.
VLCFAs made by elongases act as precursors of membrane lipids, so ELOVL3 is relevant to studies of lipid composition.
Members of the GNS1/SUR4 family supply precursors for sphingolipids and ceramides, linking ELOVL3 to sphingolipid metabolism research.
ELOVL3 catalyses the first, rate-limiting reaction of the four-step fatty acid elongation cycle in the endoplasmic reticulum, adding two carbons per cycle to long- and very long-chain fatty acids. It acts on saturated and unsaturated acyl-CoAs, with highest activity toward C18:0 acyl-CoA.
ELOVL3 stands for ELOVL fatty acid elongase 3. UniProt names the protein very long chain fatty acid elongase 3, and CIG-30 is a listed alias. The previous HGNC name was elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3. Its enzyme classification is EC 2.3.1.199.
A mouse ortholog, Elovl3, is annotated for the human gene. The protein belongs to the ELO family, ELOVL3 subfamily, and the NCBI summary places it in the GNS1/SUR4 family of fatty acid elongases. Check the datasheet of any product for its validated reactivity.
Other ELOVL fatty acid elongases and lipid-metabolism enzymes with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9HB03; product specifications from Assay Genie datasheets.