BMP8A
BMP8A (bone morphogenetic protein 8a, also known as OP-2 or Op2) is a secreted growth factor of the TGF-beta superfamily. It activates canonical BMP signalling through BMPR1A and BMPR2 and is linked to spermatogenesis, osteogenesis, steroidogenesis and energy balance. Browse Assay Genie's current range of BMP8A research reagents below, or read on for the biology behind the target.
BMP8A is a growth factor of the TGF-beta superfamily that takes part in several biological processes, including spermatogenesis, osteogenesis, steroidogenesis and the regulation of energy balance. It initiates the canonical BMP signalling cascade by associating with the type I receptor BMPR1A and the type II receptor BMPR2. Once all three components form a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. BMPR1A then propagates the signal by phosphorylating SMAD1/5/8, which move to the nucleus and act as activators and repressors of target gene transcription. BMP8A also activates the SMAD2/3 pathway.
The BMP8A gene encodes a secreted ligand. Like other members of the family, the encoded preproprotein is proteolytically processed to generate the subunits of a disulfide-linked homodimer. Ligands of this family bind TGF-beta receptors, leading to recruitment and activation of SMAD transcription factors that regulate gene expression. The BMP8A protein belongs to the TGF-beta family and is classed by HGNC in the bone morphogenetic proteins gene group. The mouse ortholog is Bmp8a.
BMP8A is also known as OP-2 (Op2). According to the NCBI Gene summary, the protein may play a role in development of the reproductive system. The gene may have arisen from a duplication event, and its duplicate, BMP8B, is also found on chromosome 1. This relationship makes BMP8A and BMP8B a useful pair to consider together when studying BMP signalling.
BMP8A signals through BMPR1A and BMPR2 to activate SMAD1/5/8 and also engages the SMAD2/3 pathway, making it a ligand for studying receptor-to-nucleus signalling.
BMP8A is implicated in spermatogenesis and may contribute to development of the reproductive system.
UniProt associates BMP8A with osteogenesis and steroidogenesis, two processes relevant to skeletal and endocrine research.
BMP8A is annotated as a regulator of energy balance, linking this TGF-beta family member to metabolic studies.
BMP8A is a secreted TGF-beta superfamily growth factor. It associates with BMPR1A and BMPR2, leading BMPR2 to activate BMPR1A, which phosphorylates SMAD1/5/8. It also activates SMAD2/3. It is linked to spermatogenesis, osteogenesis, steroidogenesis and energy balance.
BMP8A is the HGNC symbol for bone morphogenetic protein 8a. It is also known as OP-2 or Op2. The protein is processed from a preproprotein and forms a disulfide-linked homodimer, as is typical of this ligand family.
A mouse ortholog, Bmp8a, is recorded. In the human genome the gene may have arisen through duplication, and its duplicate is also on chromosome 1. Check the datasheet of any product for its validated reactivity.
Other bone morphogenetic proteins, BMP receptors and regulators relevant to TGF-beta superfamily signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q7Z5Y6; product specifications from Assay Genie datasheets.