PRDX1
PRDX1 (peroxiredoxin 1) is a thiol-specific peroxidase of the peroxiredoxin family that reduces hydrogen peroxide and organic hydroperoxides. Also known as NKEFA or PAGA, it protects cells from oxidative stress and acts as a sensor of hydrogen peroxide-mediated signalling. Browse Assay Genie's current range of PRDX1 research reagents below, or read on for the biology behind the target.
PRDX1 is a thiol-specific peroxidase that catalyses the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. By detoxifying peroxides it contributes to cell protection against oxidative stress. It also acts as a sensor of hydrogen peroxide-mediated signalling events, and by regulating intracellular H2O2 concentrations it may take part in the signalling cascades of growth factors and tumour necrosis factor-alpha.
The PRDX1 protein belongs to the peroxiredoxin family, AhpC/Prx1 subfamily, and is listed by HGNC in the peroxiredoxins gene group. UniProt records its subcellular locations as the cytoplasm and the melanosome. The PRDX1 gene has mouse and rat orthologs, both named Prdx1. According to the NCBI Gene summary, four transcript variants of the gene encode the same protein.
Beyond general antioxidant defence, PRDX1 has a specific substrate role: it reduces an intramolecular disulfide bond in GDPD5, which gates the ability of GDPD5 to drive postmitotic motor neuron differentiation. NCBI Gene also notes that the protein may contribute to the antiviral activity of CD8(+) T-cells. It may have a proliferative effect and play a role in cancer development or progression, which makes PRDX1 a frequent subject in redox biology and cancer research. The aliases NKEFA and PAGA are used in the older literature alongside the current symbol.
PRDX1 detoxifies hydrogen peroxide and organic hydroperoxides, making it a central protein for studying cellular protection against oxidative stress.
PRDX1 senses hydrogen peroxide-mediated signalling and may regulate H2O2 levels in growth factor and tumour necrosis factor-alpha cascades.
PRDX1 may have a proliferative effect and play a role in cancer development or progression, so it is studied in tumour models.
PRDX1 reduces a disulfide bond in GDPD5 that gates the ability of GDPD5 to drive postmitotic motor neuron differentiation.
PRDX1 is a thiol-specific peroxidase that reduces hydrogen peroxide and organic hydroperoxides to water and alcohols. It protects cells against oxidative stress and senses hydrogen peroxide-mediated signalling. It also reduces a disulfide bond in GDPD5, which affects motor neuron differentiation.
PRDX1 is the HGNC symbol for peroxiredoxin 1, listed in UniProt as Peroxiredoxin-1. The aliases NKEFA and PAGA also appear in the literature. NCBI Gene reports four transcript variants that all encode the same protein, so there are no distinct isoforms to separate.
Mouse and rat both have a Prdx1 ortholog. NCBI Gene states that PRDX1 may have a proliferative effect and play a role in cancer development or progression, and may contribute to CD8(+) T-cell antiviral activity. Check the datasheet of any product for its validated reactivity.
Other peroxiredoxin family members involved in antioxidant defence and hydrogen peroxide signalling, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q06830; product specifications from Assay Genie datasheets.