TOMM70
TOMM70 (translocase of outer mitochondrial membrane 70, also known as Tom70, TOMM70A or KIAA0719) is a receptor of the TOM complex in the outer mitochondrial membrane. It recognises mitochondrial preproteins and mediates their import from the cytosol. Browse Assay Genie's current range of TOMM70 research reagents below, or read on for the biology behind the target.
TOMM70 acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane, known as the TOM complex. It recognises mitochondrial preproteins in the cytosol and mediates their translocation into the mitochondria in a chaperone-dependent manner. The protein is therefore part of the core machinery by which nuclear-encoded proteins reach the organelle.
Beyond protein import, TOMM70 has a role in innate antiviral signalling. It mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during infection. After Sendai virus infection, TOMM70 recruits HSP90AA1, IRF3 and BAX to the mitochondrion, and this complex induces apoptosis.
The TOMM70 gene encodes a member of the Tom70 family, which HGNC places in the tetratricopeptide repeat domain containing group and the translocase of outer mitochondrial membrane complex group. Earlier names describe it as a yeast homologue, reflecting the original Tom70 described in yeast; the mouse and rat orthologues are both called Tomm70. The protein interacts with the ORF9b proteins of SARS-CoV and SARS-CoV-2, which has made it a point of interest in viral infection research. It is often studied alongside other TOM complex components such as TOMM20 and TOMM22.
TOMM70 is a TOM complex receptor that recognises preproteins and mediates their chaperone-dependent translocation into mitochondria.
TOMM70 mediates MAVS-induced TBK1 and IRF3 activation and promotes host antiviral responses during Sendai virus infection.
TOMM70 interacts with SARS-CoV and SARS-CoV-2 ORF9b proteins, making it relevant to studies of coronavirus interference with host mitochondria.
After Sendai virus infection, TOMM70 recruits HSP90AA1, IRF3 and BAX to mitochondria, and the complex induces apoptosis.
TOMM70 is a receptor of the TOM complex in the outer mitochondrial membrane. It recognises mitochondrial preproteins and mediates their translocation from the cytosol into mitochondria in a chaperone-dependent manner. It also supports MAVS-induced TBK1 and IRF3 activation during antiviral responses.
The gene is also known as TOMM70A and KIAA0719, and the protein as Tom70 or mitochondrial import receptor subunit TOM70. Earlier HGNC names described it as translocase of outer mitochondrial membrane 70 homolog A, a yeast homologue.
Yes. TOMM70 interacts with the ORF9b proteins of SARS-CoV and SARS-CoV-2, and it promotes antiviral responses and apoptosis after Sendai virus infection. Mouse and rat both have a Tomm70 orthologue; check the datasheet of any product for its validated reactivity.
Other TOM complex components and mitochondrial import proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O94826; product specifications from Assay Genie datasheets.