GOLGA8A
GOLGA8A (golgin A8 family member A) is a Golgi-localised golgin that may be involved in maintaining Golgi structure. It is also known as GM88, GOLGIN-67, FAP286 and CFAP286, and belongs to the GOLGA8 family. Browse Assay Genie's current range of GOLGA8A research reagents below, or read on for the biology behind the target.
GOLGA8A is a golgin, a member of the family of proteins localised to the Golgi apparatus. UniProt annotates it as a protein that may be involved in maintaining Golgi structure, and it is assigned to the Golgi stack membrane. The Golgi apparatus participates in the glycosylation and transport of proteins and lipids in the secretory pathway, and consists of a series of stacked, flattened membrane sacs called cisternae.
Interactions between the Golgi and microtubules are thought to be important for reorganising the Golgi after it fragments during mitosis. The GOLGA8A gene encodes a golgin that structurally resembles its family member GOLGA2, which suggests the two proteins may share a similar function. Researchers studying Golgi organisation often consider GOLGA8A alongside GOLGA1 and GOLGA2.
The GOLGA8A gene lies on chromosome 15, where there are many similar copies of this gene, and alternative splicing results in multiple transcript variants. This sequence similarity is worth bearing in mind when designing an experiment, for example when choosing a GOLGA8A antibody or primers. HGNC places the gene in the Golgin A6 and A8 families, and also in the groups for cilia and flagella associated genes and microRNA protein coding host genes. Earlier names include golgi autoantigen, golgin subfamily a, 8A, and the symbols GM88, GOLGIN-67 and FAP286 are still used as aliases; CFAP286 is also listed.
GOLGA8A may be involved in maintaining Golgi structure, making it a candidate for studies of how stacked cisternae are organised.
The Golgi participates in glycosylation and transport of proteins and lipids, the setting in which golgins such as GOLGA8A are studied.
Golgi–microtubule interactions are thought to be important for Golgi reorganisation after fragmentation in mitosis, a context relevant to golgin research.
GOLGA8A structurally resembles GOLGA2, so it is useful for comparing related golgins and the many similar gene copies on chromosome 15.
UniProt states that GOLGA8A may be involved in maintaining Golgi structure. It is a golgin found in the Golgi stack membrane. The Golgi apparatus takes part in glycosylation and transport of proteins and lipids in the secretory pathway, but the precise role of this protein is not fully defined.
GOLGA8A is also called Golgin subfamily A member 8A, GM88, GOLGIN-67, FAP286 and CFAP286. Previous names include golgi autoantigen, golgin subfamily a, 8A. NCBI reports that alternative splicing produces multiple transcript variants of the GOLGA8A gene.
GOLGA8A belongs to the GOLGA8 family and structurally resembles GOLGA2, suggesting a similar function. Many similar copies of the gene exist on chromosome 15. Orthologues in mouse and rat are not given in the source data, so check the datasheet of any product for its validated reactivity.
Other golgin family members and Golgi-associated proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt A7E2F4; product specifications from Assay Genie datasheets.