MCP-4
MCP-4 (C-C motif chemokine ligand 13, encoded by CCL13) is a secreted CC chemokine that attracts monocytes, lymphocytes, basophils and eosinophils. It is also known as NCC-1, SCYL1, CKb10 and SCYA13. Browse Assay Genie's current range of MCP-4 research reagents below, or read on for the biology behind the target.
MCP-4 is a chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. It signals through the CCR2B and CCR3 receptors. This pattern of target cells places it among the chemokines that shape the leukocyte populations found at sites of inflammation, and it is reported to play a role in the accumulation of leukocytes at both allergic and non-allergic inflammatory sites.
The protein belongs to the intercrine beta (chemokine CC) family, in which the defining feature is a pair of adjacent cysteines. It is a secreted protein, consistent with the wider role of cytokines as secreted mediators of immunoregulatory and inflammatory processes. The CCL13 gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17, and HGNC classes it within the chemokine ligands gene group. NCBI Gene describes it as an antimicrobial gene.
MCP-4 may be involved in recruiting monocytes into the arterial wall during atherosclerosis, and it may contribute to monocyte attraction in tissues chronically exposed to exogenous pathogens. The gene has appeared under several names, including small inducible cytokine subfamily A (Cys-Cys), member 13, and chemokine (C-C motif) ligand 13, reflecting the standardised chemokine nomenclature now in use.
MCP-4 helps drive leukocyte accumulation at allergic inflammatory sites, and it attracts eosinophils and basophils through CCR3.
The chemokine also contributes to leukocyte accumulation at non-allergic inflammatory sites, making it a useful marker of immune cell recruitment.
MCP-4 may be involved in recruiting monocytes into the arterial wall during atherosclerosis, linking chemokine signalling to vascular disease.
Signalling through CCR2B and CCR3 makes MCP-4 a relevant ligand for studying receptor usage and monocyte and lymphocyte chemotaxis.
MCP-4 is a secreted chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. It signals through CCR2B and CCR3 and contributes to leukocyte accumulation at allergic and non-allergic inflammatory sites. It may also help recruit monocytes into the arterial wall in atherosclerosis.
The official gene symbol is CCL13, for C-C motif chemokine ligand 13. Aliases include MCP-4, NCC-1, SCYL1, CKb10, MGC17134 and SCYA13. Earlier names were small inducible cytokine subfamily A (Cys-Cys), member 13, and chemokine (C-C motif) ligand 13.
MCP-4 belongs to the intercrine beta (chemokine CC) family, characterised by two adjacent cysteines. It may be involved in monocyte recruitment into the arterial wall during atherosclerosis and in monocyte attraction in tissues chronically exposed to pathogens. Check the datasheet of any product for its validated reactivity.
Other CC chemokine ligands involved in leukocyte chemotaxis and inflammatory signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99616; product specifications from Assay Genie datasheets.