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HTR3E
HTR3E is the gene encoding subunit E of the 5-hydroxytryptamine (serotonin) type 3 receptor, an ionotropic receptor of the ligand-gated ion channel family. It contributes to serotonin-activated cation channels that produce fast, depolarising responses in neurons. Browse Assay Genie's current range of HTR3E research reagents below, or read on for the biology behind the target.
The HTR3E protein, 5-hydroxytryptamine receptor 3E, forms serotonin (5-hydroxytryptamine, 5-HT3)-activated cation-selective channel complexes. When these channels are activated they cause fast, depolarising responses in neurons. Unlike the G protein-coupled serotonin receptors, the 5-HT3 receptors are ionotropic: the channel itself is the receptor, so ligand binding is coupled directly to ion flux across the membrane.
UniProt places the protein in the ligand-gated ion channel family (TC 1.A.9), within the 5-hydroxytryptamine receptor subfamily (TC 1.A.9.2) and the HTR3E sub-subfamily. It is annotated at the postsynaptic cell membrane and the cell membrane. The HTR3E gene encodes subunit E, and NCBI Gene notes that it may play a role in neurotransmission in myenteric neurons. The genes encoding subunits C, D and E form a cluster on chromosome 3, and alternatively spliced transcript variants encoding distinct isoforms have been described.
HGNC classifies the gene within the ionotropic 5-hydroxytryptamine receptors group. Earlier names include 5-hydroxytryptamine (serotonin) receptor 3, family member E, and 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic. Researchers studying serotonin signalling, subunit composition of 5-HT3 channels or enteric neurotransmission may look at the HTR3E gene and protein alongside other serotonin receptor family members.
HTR3E encodes a subunit of serotonin-activated cation channels, making it relevant to studies of ionotropic 5-HT3 receptor composition and function.
Channels containing this subunit mediate fast, depolarising responses in neurons, which is central to work on rapid synaptic signalling.
NCBI Gene notes that subunit E may play a role in neurotransmission in myenteric neurons, a focus for gut neurobiology research.
The HTR3C, HTR3D and HTR3E genes cluster on chromosome 3, and alternatively spliced variants encode distinct isoforms, offering questions in gene regulation.
HTR3E encodes subunit E of the 5-HT3 receptor. It forms serotonin-activated, cation-selective channel complexes that cause fast, depolarising responses in neurons. NCBI Gene adds that it may play a role in neurotransmission in myenteric neurons.
HGNC lists the previous names 5-hydroxytryptamine (serotonin) receptor 3, family member E, and 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic. No separate aliases are recorded. NCBI Gene also describes alternatively spliced transcript variants encoding distinct isoforms.
HTR3E belongs to the ligand-gated ion channel family and the 5-hydroxytryptamine receptor subfamily, in the HTR3E sub-subfamily. It sits in the HGNC group of ionotropic 5-hydroxytryptamine receptors, and its gene clusters with the genes for subunits C and D on chromosome 3.
Other serotonin receptor family members with products at Assay Genie, useful for comparing ionotropic and G protein-coupled serotonin signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt A5X5Y0; product specifications from Assay Genie datasheets.
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