CD27
CD27 (CD27 molecule, also known as TNFRSF7, S152 and Tp55) is a costimulatory immune-checkpoint receptor of the TNF-receptor superfamily. It binds the ligand CD70 and supports T-cell, B-cell and NK-cell immunity. Browse Assay Genie's current range of CD27 research reagents below, or read on for the biology behind the target.
CD27 is a costimulatory immune-checkpoint receptor found at the surface of T-cells, NK-cells and B-cells. It is activated by its ligand CD70 (CD27L), which is expressed by B-cells. The CD70-CD27 signalling pathway mediates antigen-specific T-cell activation and expansion, which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis, which then inhibits LCK phosphorylation to promote the phenotypic and transcriptional adaptations that underlie T-cell memory.
The receptor is required for the generation and long-term maintenance of T-cell immunity and plays a key role in regulating B-cell activation and immunoglobulin synthesis. Downstream, it transduces signals that lead to activation of NF-kappaB and MAPK8/JNK, with the adaptor proteins TRAF2 and TRAF5 mediating this signalling. The proapoptotic protein SIVA (CD27-binding protein) can also bind the receptor and is thought to contribute to apoptosis induced by CD27. Activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation, so CD27 also modulates haematopoiesis, and it negatively regulates the function of Th2 lymphocytes in adipose tissue.
The CD27 gene encodes a member of the TNF-receptor superfamily and belongs to the CD molecule gene group. HGNC lists it under the previous name tumour necrosis factor receptor superfamily, member 7, which is the origin of the TNFRSF7 symbol. The mouse ortholog is Cd27.
CD27 is a costimulatory checkpoint receptor, making it a focus for studies of how CD70 signalling shapes T-cell activation and expansion.
CD70 ligation drives the TRAF2-PTPN6 axis and inhibits LCK phosphorylation, promoting adaptations that support T-cell memory.
CD27 plays a key role in regulating B-cell activation and immunoglobulin synthesis, linking it to humoral immunity studies.
CD27 signals through TRAF2, TRAF5, NF-kappaB and MAPK8/JNK, and binds proapoptotic SIVA, offering a model for receptor-driven survival and cell death.
CD27 is a costimulatory receptor on T-cells, NK-cells and B-cells that is activated by CD70. It promotes antigen-specific T-cell activation and expansion, supports T-cell memory, and helps regulate B-cell activation and immunoglobulin synthesis through NF-kappaB and JNK signalling.
CD27 is also known as TNFRSF7, S152 and Tp55. UniProt calls the protein CD27 antigen, and HGNC gives the full name as CD27 molecule, with the previous name tumour necrosis factor receptor superfamily, member 7. The ligand is CD70, also called CD27L.
A mouse ortholog, Cd27, is recorded in the gene data. No rat ortholog is listed in the data supplied here. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other CD molecules and immune cell markers that are useful alongside CD27 in lymphocyte and immune-regulation research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P26842; product specifications from Assay Genie datasheets.