CSRP1
CSRP1 (cysteine and glycine rich protein 1, also known as CSRP, D1S181E and CYRP) is a member of the cysteine-rich protein family of LIM domain proteins. It is thought to contribute to regulatory processes in development and cellular differentiation. Browse Assay Genie's current range of CSRP1 research reagents below, or read on for the biology behind the target.
CSRP1 belongs to the cysteine-rich protein (CSRP) family, a group of LIM domain proteins that may be involved in regulatory processes important for development and cellular differentiation. UniProt annotates the protein as one that could play a role in neuronal development, although this function is described tentatively. The protein localises to the nucleus.
The CSRP1 protein carries a LIM/double zinc-finger motif. According to the NCBI Gene summary, this motif occurs in proteins with critical functions in gene regulation, cell growth and somatic differentiation. HGNC places the gene in the LIM domain containing group, alongside other proteins built around this zinc-binding module.
The CSRP1 gene is also known by the aliases CSRP, D1S181E and CYRP, and has orthologues named Csrp1 in both mouse and rat. Alternatively spliced transcript variants have been described for the gene, so researchers studying CSRP1 expression should consider which transcripts their assay design captures. The protein is a useful subject for work on LIM domain biology, transcriptional regulation and differentiation.
UniProt annotates CSRP1 as a protein that could play a role in neuronal development, making it a candidate for developmental neuroscience studies.
CSRP family proteins may be involved in regulatory processes important for cellular differentiation, and CSRP1 is studied in that context.
The LIM/double zinc-finger motif in CSRP1 occurs in proteins with critical functions in gene regulation, and the protein is found in the nucleus.
As a member of the LIM domain containing group, CSRP1 is a reference point for comparing LIM proteins in cell growth and differentiation.
CSRP1 is a nuclear LIM domain protein of the cysteine-rich protein family. The family may be involved in regulatory processes important for development and cellular differentiation, and UniProt notes that CSRP1 could play a role in neuronal development. Its precise functions are not fully defined in the source annotations.
The gene symbol CSRP1 stands for cysteine and glycine rich protein 1. Aliases and previous symbols include CSRP, D1S181E and CYRP. The NCBI Gene summary notes that alternatively spliced transcript variants have been described, so more than one transcript may arise from the gene.
Yes. Orthologues named Csrp1 are recognised in both mouse and rat, which allows rodent models to be used for studying this LIM domain protein. Researchers should check the datasheet of any product for its validated reactivity.
Other CSRP family members and LIM domain proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P21291; product specifications from Assay Genie datasheets.