DLGAP5
DLGAP5 (DLG associated protein 5, also known as HURP, DLG7 and KIAA0008) is a mitotic phosphoprotein of the SAPAP family. It is a potential cell cycle regulator that may play a role in the carcinogenesis of cancer cells. Browse Assay Genie's current range of DLGAP5 research reagents below, or read on for the biology behind the target.
DLGAP5 is described as a potential cell cycle regulator that may contribute to the carcinogenesis of cancer cells. It is a mitotic phosphoprotein whose levels are regulated by the ubiquitin-proteasome pathway. UniProt also annotates it as a key regulator of adherens junction integrity and differentiation, and suggests it may be involved in CDH1-mediated adhesion and signalling in epithelial cells.
The DLGAP5 protein belongs to the SAPAP family and is found in the nucleus and cytoplasm, including the cytoskeleton of the spindle. NCBI Gene, drawing on Alliance of Genome Resources predictions, indicates that it is predicted to enable microtubule binding and to be involved in centrosome localisation, kinetochore assembly and mitotic spindle organisation. It is reported in the cytosol, nucleus and spindle. The mouse ortholog is Dlgap5.
The DLGAP5 gene has a long list of names. Aliases and previous symbols include KIAA0008, DLG1, HURP and DLG7, and earlier names were discs, large homolog 7 (Drosophila) and discs, large (Drosophila) homolog-associated protein 5. The official HGNC name is DLG associated protein 5, and UniProt lists the protein as disks large-associated protein 5. Researchers working on mitosis, spindle biology and cancer cell proliferation will often meet it under the HURP name.
DLGAP5 is a mitotic phosphoprotein and potential cell cycle regulator, making it relevant to studies of how cells progress through mitosis.
Predicted microtubule binding and roles in spindle organisation, centrosome localisation and kinetochore assembly make DLGAP5 a candidate for spindle studies.
UniProt notes that DLGAP5 may play a role in the carcinogenesis of cancer cells, which supports its study in tumour cell proliferation.
DLGAP5 is annotated as a regulator of adherens junction integrity and may act in CDH1-mediated adhesion and signalling in epithelial cells.
DLGAP5 is a potential cell cycle regulator and mitotic phosphoprotein controlled by the ubiquitin-proteasome pathway. UniProt also describes it as a key regulator of adherens junction integrity and differentiation, possibly involved in CDH1-mediated adhesion and signalling in epithelial cells. It is predicted to bind microtubules and to help organise the mitotic spindle.
HURP, DLG7, DLG1 and KIAA0008 are aliases or previous symbols for the same gene. The earlier names, such as discs, large homolog 7 (Drosophila), reflect its original link to the Drosophila discs large family. The current HGNC name is DLG associated protein 5, and the protein belongs to the SAPAP family.
A mouse ortholog, Dlgap5, is recognised. UniProt states that DLGAP5 may play a role in the carcinogenesis of cancer cells, though it is described as a potential regulator. Check the datasheet of any product for its validated reactivity.
Other SAPAP family members, adherens junction proteins and cell cycle regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15398; product specifications from Assay Genie datasheets.