RNF130
RNF130 (ring finger protein 130, also known as GP, G1RZFP and GOLIATH) is a RING finger E3 ubiquitin-protein ligase. It has been linked to the programmed cell death of haematopoietic cells and to growth factor withdrawal-induced apoptosis in myeloid precursors. Browse Assay Genie's current range of RNF130 research reagents below, or read on for the biology behind the target.
RNF130 acts as an E3 ubiquitin-protein ligase, the class of enzyme that confers substrate specificity on the ubiquitin system. UniProt annotates it as possibly having a role in the programmed cell death of haematopoietic cells. The protein contains a RING finger motif, the domain type that defines the RING finger E3 ligases. UniProt lists its subcellular location as membrane and cytoplasm.
The human RNF130 gene encodes a protein similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. Alternative splicing of the RNF130 gene results in multiple transcript variants. Orthologues are present in mouse and rat, both designated Rnf130.
The NCBI Gene summary reports that expression of the mouse counterpart is upregulated in myeloblastic cells following IL-3 deprivation. This suggests that RNF130 may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. The protein is also known as GP, G1RZFP and GOLIATH. HGNC places it in the groups of ring finger proteins, RING finger E3 ubiquitin protein ligases and microRNA protein coding host genes.
RNF130 is implicated in growth factor withdrawal-induced apoptosis, making it relevant to studies of programmed cell death.
Upregulation in myeloblastic cells after IL-3 deprivation points to a role in the fate of myeloid precursor cells.
As a RING finger E3 ubiquitin-protein ligase, RNF130 is a candidate for studying substrate selection in ubiquitination.
Similarity to the Drosophila zinc-finger protein g1, expressed in mesoderm, links RNF130 to questions about embryonic development.
RNF130 acts as an E3 ubiquitin-protein ligase and may have a role in the programmed cell death of haematopoietic cells. Mouse data suggest it may regulate apoptosis in myeloid precursor cells after growth factor withdrawal. Check the datasheet of any product for its validated reactivity.
RNF130 is the HGNC symbol for ring finger protein 130. Aliases include GP, G1RZFP and GOLIATH. UniProt names the protein E3 ubiquitin-protein ligase RNF130. Alternative splicing of the gene produces multiple transcript variants.
Yes. Mouse and rat both carry an orthologous Rnf130 gene. The human protein is also similar to g1, a Drosophila zinc-finger protein expressed in mesoderm and involved in embryonic development, and the mouse counterpart is upregulated after IL-3 deprivation.
Other RING finger proteins and E3 ubiquitin ligases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q86XS8; product specifications from Assay Genie datasheets.