RASSF4
RASSF4 (Ras association domain family member 4, also known as AD037 or MGC44914) is a member of the Ras association domain family. It is considered a potential tumour suppressor and may act as a KRAS effector protein. Browse Assay Genie's current range of RASSF4 research reagents below, or read on for the biology behind the target.
RASSF4 is annotated in UniProt as a potential tumour suppressor. It may act as a KRAS effector protein, linking Ras signalling to downstream responses, and it may promote apoptosis and cell cycle arrest. These roles are described as possible rather than established, and the precise molecular function of the protein is still being defined.
The RASSF4 gene encodes Ras association domain-containing protein 4. HGNC places it in the Ras association domain family, and it has mouse and rat orthologs, both named Rassf4. According to the NCBI Gene summary, the function of the gene has not yet been fully determined, but it may involve a role in tumour suppression. Alternative splicing of the gene produces several transcript variants, most of which have not been fully described. A subcellular location is not currently annotated in UniProt.
The gene was previously named Ras association (RalGDS/AF-6) domain family member 4, and earlier symbols include AD037 and MGC44914. Researchers studying RASSF4 usually do so in the context of other RASSF family members, comparing how each one connects Ras signalling with growth control, apoptosis and cell cycle regulation.
RASSF4 is a potential tumour suppressor, so it is studied in work on how growth-restraining proteins are lost or altered in cancer.
RASSF4 may act as a KRAS effector protein, making it relevant to studies of how Ras signals are passed to downstream partners.
RASSF4 may promote apoptosis and cell cycle arrest, which makes it a candidate for investigating cell fate decisions.
As a member of the Ras association domain family, RASSF4 is used in comparative studies of related RASSF proteins and their roles.
UniProt describes RASSF4 as a potential tumour suppressor that may act as a KRAS effector protein and may promote apoptosis and cell cycle arrest. The NCBI Gene summary notes that its function has not yet been fully determined but may involve tumour suppression.
RASSF4 is also known as AD037 and MGC44914, and was previously named Ras association (RalGDS/AF-6) domain family member 4. NCBI reports that alternative splicing yields several transcript variants, though most have not been fully described.
Yes. Mouse and rat orthologs, both called Rassf4, are recorded for the human gene. RASSF4 also belongs to the wider Ras association domain family, which includes RASSF1, RASSF2, RASSF6, RASSF7 and RASSF9. Check the datasheet of any product for its validated reactivity.
Other members of the Ras association domain family that are studied alongside RASSF4 in tumour suppression and Ras signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H2L5; product specifications from Assay Genie datasheets.