Nectin-2
Nectin-2, encoded by the NECTIN2 gene and also known as CD112, PVRL2, PRR2 and HVEB, is a single-pass type I membrane glycoprotein of the nectin family. It is a plasma membrane component of adherens junctions and a viral entry receptor. Browse Assay Genie's current range of Nectin-2 research reagents below, or read on for the biology behind the target.
Nectin-2 is a single-pass type I membrane glycoprotein that sits in the cell membrane and is one of the plasma membrane components of adherens junctions. Its extracellular region contains an Ig-like V-type domain and two Ig-like C2-type domains, an architecture reflected in its HGNC classification within the V-set and C2-set domain containing groups and the nectins and nectin-like molecules.
Nectin-2 also acts as an entry receptor for certain viruses. According to UniProt, it serves as a receptor for the herpes simplex virus 1 mutant Rid1, for herpes simplex virus 2 and for pseudorabies virus. NCBI Gene adds that it is involved in cell-to-cell spreading of these viruses, which makes it a useful reference point for studies of herpesvirus entry and spread.
The NECTIN2 gene is designated CD112 in the CD molecule nomenclature, and earlier names include poliovirus receptor-related 2 (herpesvirus entry mediator B), reflected in the aliases PVRR2, PRR2, HVEB and PVRL2. Variations in the gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants encoding different isoforms have been characterised. Nectin-2 belongs to the nectin family alongside NECTIN1, NECTIN3 and Nectin-4, and the mouse ortholog is Nectin2.
Nectin-2 is a plasma membrane component of adherens junctions, making it relevant to studies of cell-to-cell contact.
Nectin-2 serves as a receptor for herpes simplex virus 2, the herpes simplex virus 1 mutant Rid1 and pseudorabies virus.
Nectin-2 is involved in cell-to-cell spreading of certain mutant herpes simplex virus strains and pseudorabies virus.
Variations in the NECTIN2 gene have been associated with differences in the severity of multiple sclerosis.
Nectin-2 is a plasma membrane component of adherens junctions. It also acts as an entry receptor for herpes simplex virus 2, the herpes simplex virus 1 mutant Rid1 and pseudorabies virus, and is involved in cell-to-cell spreading of these viruses.
Nectin-2 is also called CD112, PVRL2, PRR2, PVRR2 and HVEB. Its earlier name was poliovirus receptor-related 2 (herpesvirus entry mediator B). Alternate transcriptional splice variants encoding different isoforms have been described for the NECTIN2 gene.
Variations in the NECTIN2 gene have been associated with differences in the severity of multiple sclerosis. A mouse ortholog, Nectin2, exists. Check the datasheet of any product for its validated reactivity.
Other nectin family members and adherens junction adhesion molecules with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92692; product specifications from Assay Genie datasheets.