TRPC1
TRPC1 (transient receptor potential cation channel subfamily C member 1, also known as short transient receptor potential channel 1 or HTRP-1) is a plasma membrane protein that forms a receptor-activated, non-selective calcium-permeant cation channel. It is also activated when intracellular calcium stores are depleted. Browse Assay Genie's current range of TRPC1 research reagents below, or read on for the biology behind the target.
TRPC1 forms a non-selective channel that is permeable to calcium and other cations. Two modes of activation are described: the channel is receptor-activated, and it is also activated by depletion of intracellular calcium stores. NCBI Gene summarises the receptor route as induction of channel formation by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system. This places the TRPC1 protein at the point where cell-surface signalling and intracellular calcium handling meet, and it is the reason the channel is studied in calcium signalling research.
The TRPC1 gene encodes a membrane protein that localises to the cell membrane. UniProt classifies it in the transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC1 sub-subfamily. HGNC places it in two gene groups: ankyrin repeat domain containing proteins, and the transient receptor potential cation channel subfamily C. It has no assigned enzymatic activity. Two transcript variants encoding different isoforms have been reported for the gene. Mouse and rat each have a Trpc1 ortholog, which allows work on the channel in rodent models.
The approved HGNC name is transient receptor potential cation channel subfamily C member 1. The earlier name used the form 'transient receptor potential cation channel, subfamily C, member 1', and HTRP-1 is a recorded alias. Other members of the TRPC subfamily, including TRPC5 and TRPC6, are studied alongside TRPC1 when researchers compare how receptor-operated cation channels are regulated. Researchers looking for a TRPC1 antibody or a TRPC1 ELISA kit usually do so to follow channel expression in these calcium signalling studies.
TRPC1 forms a calcium-permeant cation channel, making it a focus for work on how cells control calcium entry.
The channel is activated by depletion of intracellular calcium stores, so it is relevant to studies of store-dependent activation.
Channel formation is induced through a receptor tyrosine kinase-activated phosphatidylinositol second messenger system, linking TRPC1 to receptor-driven pathways.
As a member of the TRPC subfamily, TRPC1 is used to study how related cation channels differ in structure and activation.
TRPC1 forms a non-selective cation channel in the cell membrane that is permeable to calcium. It is activated downstream of receptors and also by depletion of intracellular calcium stores, so it contributes to calcium entry in response to cell signalling.
TRPC1 is also called short transient receptor potential channel 1 and HTRP-1. Its older HGNC name was transient receptor potential cation channel, subfamily C, member 1. NCBI Gene reports two transcript variants that encode different isoforms.
Yes. Mouse and rat both have an ortholog named Trpc1, so the channel can be studied in rodent systems. Check the datasheet of any product for its validated reactivity before using it in a particular species.
Other TRPC subfamily channels and TRPC-associated proteins studied in calcium signalling research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P48995; product specifications from Assay Genie datasheets.