ADSS2
ADSS2 (adenylosuccinate synthase 2, also known as ADSS) is an enzyme of purine nucleotide metabolism. It catalyses the first committed step in the biosynthesis of AMP from IMP, and acts in both the de novo and salvage purine pathways. Browse Assay Genie's current range of ADSS2 research reagents below, or read on for the biology behind the target.
ADSS2 is the adenylosuccinate synthetase isozyme 2, an enzyme that plays an important role in both the de novo pathway and the salvage pathway of purine nucleotide biosynthesis. It catalyses the first committed step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP), which commits IMP to the adenine nucleotide branch of purine metabolism rather than other fates.
The ADSS2 gene encodes a protein of the adenylosuccinate synthetase family, classified under EC 6.3.4.4. UniProt records the protein in the cytoplasm and the mitochondrion. The mouse ortholog is designated Adss2. According to the NCBI Gene summary, a pseudogene of this gene is found on chromosome 17, which is worth bearing in mind when designing nucleic acid based assays for the ADSS2 gene.
The approved HGNC name is adenylosuccinate synthase 2, and the gene was previously known by the symbol ADSS and the name adenylosuccinate synthase. Older literature and some resources may therefore refer to the enzyme simply as ADSS. Researchers studying purine nucleotide supply, AMP biosynthesis or the balance between de novo and salvage routes will find ADSS2 a central enzyme to examine, whether through an ADSS2 antibody for protein detection or an ADSS2 ELISA kit for quantitation.
ADSS2 plays an important role in the de novo and salvage pathways of purine nucleotide biosynthesis, making it a key enzyme to study.
As the catalyst of the first committed step from IMP to AMP, ADSS2 is a focal point for studying adenine nucleotide production.
ADSS2 belongs to the adenylosuccinate synthetase family, supporting comparative work on isozymes and their roles in nucleotide metabolism.
ADSS2 is reported in both the cytoplasm and the mitochondrion, relevant to studies of compartmentalised purine metabolism.
ADSS2 catalyses the first committed step in the biosynthesis of AMP from IMP. UniProt describes it as playing an important role in both the de novo pathway and the salvage pathway of purine nucleotide biosynthesis.
The HGNC-approved name is adenylosuccinate synthase 2. The gene was previously known as ADSS, with the earlier name adenylosuccinate synthase. UniProt lists the protein as adenylosuccinate synthetase isozyme 2, and the enzyme carries the EC number 6.3.4.4.
The mouse ortholog is Adss2. The NCBI Gene summary also notes a pseudogene of this gene on chromosome 17, which can matter for nucleic acid assays. Check the datasheet of any product for its validated reactivity.
Other purine biosynthesis enzymes and nucleotide-metabolism targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P30520; product specifications from Assay Genie datasheets.