ESRRG
ESRRG (oestrogen related receptor gamma, also known as NR3B3, ERRg and ERR-gamma) is an orphan nuclear receptor that activates transcription without a bound ligand. It binds oestrogen response elements and belongs to the NR3 subfamily of the nuclear hormone receptor family. Browse Assay Genie's current range of ESRRG research reagents below, or read on for the biology behind the target.
ESRRG is an orphan receptor that acts as a transcription activator in the absence of bound ligand. It binds specifically to an oestrogen response element and activates reporter genes controlled by these elements. NCBI Gene also reports binding to the steroidogenic factor 1 response element, with activation of genes controlled by both element types without any ligand. In skeletal muscle, the ESRRG protein induces expression of PERM1.
The ESRRG gene encodes a member of the oestrogen receptor-related receptor (ESRR) family within the nuclear hormone receptor superfamily. All ESRR members share an almost identical DNA binding domain made up of two C4-type zinc finger motifs. The family is closely related to the oestrogen receptor (ER) family: the two share target genes, co-regulators and promoters, so the ESRRs appear to interfere with the ER-mediated oestrogen response in several ways. Multiple alternatively spliced transcript variants have been identified. They differ mainly at the 5' end, and some encode isoforms that differ in the N-terminal region.
Reported roles for ESRRG include acting as a transcriptional activator of DNMT1 expression by binding directly to response elements in the DNMT1 promoters. It is also reported to modulate cell proliferation and oestrogen signalling in breast cancer, and to negatively regulate bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. The gene is grouped by HGNC with the oestrogen related receptors, and mouse and rat both have an orthologous Esrrg gene.
ESRRG activates transcription from oestrogen response elements without a ligand, making it a useful model of orphan nuclear receptor function.
ESRRG is reported to modulate cell proliferation and oestrogen signalling in breast cancer, overlapping with the ER-mediated response.
ESRRG negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation, linking it to bone development studies.
ESRRG binds response elements in DNMT1 promoters and activates DNMT1 expression, connecting orphan receptors to DNA methylation machinery.
ESRRG is an orphan nuclear receptor that activates transcription without a bound ligand. It binds oestrogen response elements and activates genes controlled by them. In skeletal muscle it induces PERM1 expression, and it is reported to activate DNMT1 expression through direct promoter binding.
ESRRG is also called NR3B3, ERRg and ERR-gamma, and its full name is oestrogen related receptor gamma. The gene produces several alternatively spliced transcript variants that differ mainly at the 5' end, and some encode isoforms differing in the N-terminal region.
The ESRR family is closely related to the oestrogen receptor family. They share target genes, co-regulators and promoters, so ESRRs appear to interfere with ER-mediated oestrogen responses in various ways. Mouse and rat Esrrg are orthologues; check the datasheet of any product for its validated reactivity.
Other oestrogen related receptors, oestrogen receptors and downstream targets of ESRRG with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P62508; product specifications from Assay Genie datasheets.