HTR2A
HTR2A (5-hydroxytryptamine receptor 2A, also known as 5-HT2A or HTR2) is one of the receptors for serotonin, a neurotransmitter with many roles. It belongs to the G protein-coupled receptor 1 family and is also a receptor for human JC polyomavirus. Browse Assay Genie's current range of HTR2A research reagents below, or read on for the biology behind the target.
HTR2A encodes one of the receptors for serotonin (5-hydroxytryptamine), a neurotransmitter with many roles. The protein belongs to the G protein-coupled receptor 1 family and sits in the HGNC gene group of 5-hydroxytryptamine receptors, G protein-coupled. In addition to its role as a serotonin receptor, UniProt annotates HTR2A as a receptor for human JC polyomavirus (JCPyV) in the context of microbial infection.
UniProt records the HTR2A protein at the cell membrane, and also in dendrites, axons, cytoplasmic vesicles, caveolae and the presynapse. This distribution is consistent with a receptor that is found at neuronal compartments as well as at the cell surface. Multiple transcript variants encoding different isoforms have been reported for the HTR2A gene. Mouse and rat both have an orthologous gene, Htr2a, which allows the receptor to be studied in common model species.
The gene has been studied extensively in psychiatric genetics. According to the NCBI Gene summary, mutations in HTR2A are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also carry a mutation in intron 2 of the gene show a significantly reduced response to citalopram, as this antidepressant downregulates expression of the gene. Earlier names for the gene include 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, and the symbol HTR2. Researchers studying HTR2A may use an HTR2A antibody or related reagents to examine receptor expression and localisation.
HTR2A variants are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, making the gene a recurrent subject in psychiatric genetic studies.
HTR2A is linked to response to citalopram in major depressive disorder, and the drug downregulates its expression.
As one of the serotonin receptors in the G protein-coupled receptor 1 family, HTR2A is studied to understand the many roles of serotonin.
UniProt annotates HTR2A as a receptor for human JC polyomavirus, relevant to studies of viral entry.
HTR2A encodes one of the receptors for serotonin, a neurotransmitter with many roles. It is a G protein-coupled receptor of the GPCR 1 family. UniProt also annotates it as a receptor for human JC polyomavirus during microbial infection.
HTR2A is also called 5-HT2A and HTR2, and its full name is 5-hydroxytryptamine receptor 2A. Earlier HGNC names were 5-hydroxytryptamine (serotonin) receptor 2A, with a G protein-coupled variant. Multiple transcript variants encoding different isoforms have been described.
Mutations in HTR2A are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and with citalopram response in major depressive disorder. Mouse and rat both carry an orthologous Htr2a gene; check the datasheet of any product for its validated reactivity.
Other 5-hydroxytryptamine receptor family members and serotonin signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P28223; product specifications from Assay Genie datasheets.