CYSLTR1
CYSLTR1 (cysteinyl leukotriene receptor 1, also written CysLT1 or CYSLT1R) is a G protein-coupled receptor on the cell membrane. It binds cysteinyl leukotrienes and mediates bronchoconstriction through a phosphatidylinositol-calcium second messenger system. Browse Assay Genie's current range of CYSLTR1 research reagents below, or read on for the biology behind the target.
CYSLTR1 is the receptor for cysteinyl leukotrienes and mediates bronchoconstriction in individuals with and without asthma. Stimulation by LTD4 leads to contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. This response is transmitted through a G protein that activates a phosphatidylinositol-calcium second messenger system. The receptor shows a clear rank order of affinity for leukotrienes: LTD4 binds far more strongly than LTE4 or LTC4, which are equivalent to each other, and all three bind more strongly than LTB4.
The CYSLTR1 gene encodes a member of the G protein-coupled receptor 1 family, and HGNC classifies it in the leukotriene receptors gene group. The protein is found at the cell membrane. Alternative splicing of the gene results in multiple transcript variants. Researchers studying the CYSLTR1 protein will often work alongside its relative CYSLTR2, which belongs to the same cysteinyl leukotriene receptor set. Orthologous genes are recognised in mouse and rat, both named Cysltr1, which allows the receptor to be examined in rodent models of airway biology.
In terms of disease relevance, upregulation of the CYSLTR1 gene is associated with asthma, and dysregulation may also be implicated in cancer. Together with its roles in smooth muscle contraction, eosinophil migration and mucus layer damage, this makes the receptor a focus for work on airway inflammation and leukotriene signalling. The gene is also known by the aliases CysLT1, CysLT(1) and CYSLT1R, so literature searches benefit from including all of these names.
CYSLTR1 is upregulated in asthma and mediates bronchoconstriction, making it central to studies of airway smooth muscle responses.
The receptor binds LTD4 with far greater affinity than LTE4, LTC4 or LTB4, which defines its ligand selectivity.
CYSLTR1 acts through a G protein that activates a phosphatidylinositol-calcium second messenger system, a model for calcium-coupled signalling.
Eosinophil migration and mucus layer damage follow receptor activation, and dysregulation of CYSLTR1 may also be implicated in cancer.
CYSLTR1 is a receptor for cysteinyl leukotrienes. When stimulated by LTD4, it signals through a G protein and a phosphatidylinositol-calcium second messenger system. This drives smooth muscle contraction and proliferation, oedema, eosinophil migration and damage to the mucus layer in the lung, causing bronchoconstriction.
CYSLTR1 is also written CysLT1, CysLT(1) and CYSLT1R, and its full name is cysteinyl leukotriene receptor 1. NCBI Gene reports that alternative splicing results in multiple transcript variants. Check the datasheet of any product for its validated reactivity and the isoforms it detects.
Upregulation of the CYSLTR1 gene is associated with asthma, and dysregulation may also be implicated in cancer. Mouse and rat each have an ortholog named Cysltr1. Check the datasheet of any product for its validated reactivity before using it in a given species.
The other cysteinyl leukotriene receptor, CYSLTR2, with related products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y271; product specifications from Assay Genie datasheets.