TNFRSF19
TNFRSF19, also known as TROY, TAJ, TAJ-alpha and TRADE, is a membrane receptor of the tumour necrosis factor receptor superfamily. It can activate JNK and NF-kappa-B signalling and may promote caspase-independent cell death. Browse Assay Genie's current range of TNFRSF19 research reagents below, or read on for the biology behind the target.
TNFRSF19 (tumour necrosis factor receptor superfamily member 19) is a membrane receptor that can mediate activation of JNK and NF-kappa-B. It has been shown to interact with members of the TRAF family, and when overexpressed in cells it activates the JNK signalling pathway. It may also promote cell death by a caspase-independent mechanism, and it is capable of inducing apoptosis through that route.
The TNFRSF19 gene belongs to the HGNC gene group for the tumour necrosis factor receptor superfamily, and its product is a member of the TNF-receptor superfamily. The receptor is highly expressed during embryonic development and is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. The mouse ortholog is Tnfrsf19.
The protein is known by several names: TROY, TAJ, TAJ-alpha and TRADE, and the previous HGNC name was tumour necrosis factor receptor superfamily, member 19. Researchers studying the TNFRSF19 gene or protein usually do so in the context of TRAF-dependent signalling, JNK and NF-kappa-B activation, and non-canonical cell death mechanisms that do not depend on caspases.
TNFRSF19 is highly expressed during embryonic development and is thought to play an essential role in it, making it a target for developmental biology.
Overexpression of the receptor activates JNK signalling, so it is used to study how TNF receptor family members engage stress-kinase cascades.
TNFRSF19 can mediate NF-kappa-B activation, which supports work on receptor-proximal signalling within the TNF receptor superfamily.
The receptor can induce apoptosis by a caspase-independent mechanism, which makes it relevant to studies of alternative cell death routes.
TNFRSF19 is a membrane receptor of the TNF receptor superfamily. It can mediate activation of JNK and NF-kappa-B, interacts with TRAF family members, and may promote caspase-independent cell death. It is thought to play an essential role in embryonic development.
TNFRSF19 is also called TROY, TAJ, TAJ-alpha and TRADE. Its earlier HGNC name was tumour necrosis factor receptor superfamily, member 19. Alternatively spliced transcript variants encoding distinct isoforms have been described, so check the datasheet of any product for its validated reactivity.
A mouse ortholog, Tnfrsf19, is recorded for the human gene. The receptor is highly expressed during embryonic development, a feature that makes the mouse gene useful for developmental work. Check the datasheet of any product for its validated reactivity.
Other TNF receptor superfamily members with related signalling and cell death roles.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NS68; product specifications from Assay Genie datasheets.