EPDR1
EPDR1 (ependymin related 1) is a glycosylated member of the ependymin family that binds anionic lipids and gangliosides at acidic pH. It is also known as MERP-1, MERP1, UCC1 and EPDR, and may contribute to calcium-dependent cell adhesion. Browse Assay Genie's current range of EPDR1 research reagents below, or read on for the biology behind the target.
EPDR1 is a mammalian ependymin-related protein that binds anionic lipids and gangliosides at acidic pH. This property fits its reported localisation in the lysosome lumen, an acidic compartment, and it is also annotated as a secreted protein. The NCBI Gene summary notes that the orthologous mouse protein is localised to the lysosome, and that the human protein is glycosylated.
The EPDR1 gene encodes a protein that NCBI Gene describes as a type II transmembrane protein, similar to two families of cell adhesion molecules: the protocadherins and the ependymins. On this basis, EPDR1 may play a role in calcium-dependent cell adhesion. UniProt places it in the ependymin family. Alternative splicing of the EPDR1 gene gives rise to multiple transcript variants, and a related pseudogene has been identified on chromosome 8. Orthologous genes are named Epdr1 in both mouse and rat.
The protein is known by several names. HGNC lists the approved name as ependymin related 1, with previous name ependymin related protein 1 (zebrafish), and the aliases MERP-1, MERP1, UCC1 and EPDR. The name MERP reflects its status as a mammalian ependymin-related protein. Researchers studying EPDR1 typically focus on its lipid-binding behaviour in acidic compartments, its glycosylation and its possible role in cell adhesion.
EPDR1 is reported in the lysosome lumen and binds anionic lipids and gangliosides at acidic pH, making it relevant to lysosomal lipid studies.
UniProt annotates EPDR1 as binding anionic lipids and gangliosides at acidic pH, a feature studied in lipid-protein interaction work.
Similarity to protocadherins and ependymins suggests EPDR1 may take part in calcium-dependent cell adhesion.
As a mammalian relative of the ependymins, EPDR1 offers a route to comparing family members across species.
UniProt annotates EPDR1 as binding anionic lipids and gangliosides at acidic pH. NCBI Gene adds that, owing to its similarity to protocadherins and ependymins, it may play a role in calcium-dependent cell adhesion. It is found in the lysosome lumen and is also secreted.
EPDR1 is also called MERP-1, MERP1, UCC1 and EPDR, and its previous HGNC name was ependymin related protein 1 (zebrafish). NCBI Gene reports that alternative splicing produces multiple transcript variants of the EPDR1 gene.
Yes. Mouse and rat both carry an orthologous gene named Epdr1, and the NCBI Gene summary notes that the mouse protein is localised to the lysosome. Check the datasheet of any product for its validated reactivity.
Other ependymin-family, lysosomal and cell adhesion targets with research reagents at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UM22; product specifications from Assay Genie datasheets.