LILRB3
LILRB3 (leukocyte immunoglobulin-like receptor subfamily B member 3, also known as CD85a, ILT5, LIR-3, HL9 and PIR-B) is a cell-surface inhibitory receptor of the LIR family. It carries ITIMs and dampens immune cell activation. Browse Assay Genie's current range of LILRB3 research reagents below, or read on for the biology behind the target.
LILRB3 may act as a receptor for class I MHC antigens. According to the NCBI Gene summary, the receptor is expressed on immune cells, where it binds MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity, helping to focus the immune response and limit autoreactivity.
The inhibitory activity of LILRB3 depends on its immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor becomes activated upon coligation of LILRB3 with other immune receptors, such as FCGR2B and the B-cell receptor. Once engaged, it down-regulates antigen-induced B-cell activation by recruiting phosphatases to its ITIMs. This makes LILRB3 a useful model for studying how inhibitory receptors set the threshold of immune activation.
The LILRB3 gene belongs to the leukocyte immunoglobulin-like receptor (LIR) cluster. The encoded protein is a subfamily B member, a class of LIR receptors with two or four extracellular immunoglobulin domains, a transmembrane domain and two to four cytoplasmic ITIMs. LILRB3 is a CD molecule and sits in the HGNC group of inhibitory leukocyte immunoglobulin like receptors. Multiple transcript variants encoding different isoforms have been described. The mouse ortholog is Pirb, which explains the PIR-B alias found in the literature. Researchers studying LILRB3 often work alongside other LILRB family members when comparing inhibitory receptor signalling.
As an ITIM-bearing receptor that transduces negative signals, LILRB3 is relevant to studies of how immune responses are restrained.
LILRB3 down-regulates antigen-induced B-cell activation by recruiting phosphatases, making it a subject for B-cell receptor signalling research.
LILRB3 may act as a receptor for class I MHC antigens on antigen-presenting cells, supporting work on immune self-recognition.
The receptor is thought to control inflammatory responses and cytotoxicity and to limit autoreactivity, linking it to immune tolerance research.
LILRB3 is an inhibitory receptor that may bind class I MHC antigens. When coligated with receptors such as FCGR2B or the B-cell receptor, it recruits phosphatases to its ITIMs and down-regulates antigen-induced B-cell activation, helping limit immune responses.
LILRB3 is also called CD85a, ILT5, LIR-3, LIR3, HL9 and PIR-B. Its earlier name was leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3. Multiple transcript variants encoding different isoforms have been reported.
The mouse ortholog of LILRB3 is Pirb, and the PIR-B alias reflects this link. LILRB3 belongs to the LIR family cluster on human chromosome 19q13.4. Check the datasheet of any product for its validated reactivity.
Other inhibitory leukocyte immunoglobulin-like receptors of the LILRB subfamily with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75022; product specifications from Assay Genie datasheets.