ACRV1
ACRV1 (acrosomal vesicle protein 1) is a testis-specific differentiation antigen found in the acrosome of sperm. It is also known as SP-10, SPACA2 and D11S4365, and UniProt lists it as acrosomal protein SP-10. Browse Assay Genie's current range of ACRV1 research reagents below, or read on for the biology behind the target.
ACRV1 is a testis-specific differentiation antigen that arises within the acrosomal vesicle during spermatogenesis. In mature sperm it is associated with the acrosomal membranes and matrix. The acrosome is a secretory vesicle at the head of the sperm, and UniProt assigns ACRV1 to the cytoplasmic vesicle, secretory vesicle and acrosome compartments.
According to the NCBI Gene summary, ACRV1 may be involved in sperm-zona binding or penetration. This points to a role in the interaction between sperm and the egg coat at fertilisation. The summary words this cautiously, and the precise molecular mechanism is not described in the sources used here.
The ACRV1 gene is annotated as encoding acrosomal vesicle protein 1, and alternatively spliced transcript variants have been described. The protein is also called SP-10, and the aliases SPACA2 and D11S4365 appear in gene records. A mouse ortholog, Acrv1, is recognised. Because of its restricted expression in the male germline and its acrosomal localisation, ACRV1 is a useful marker for studying acrosome biogenesis and sperm function.
ACRV1 arises within the acrosomal vesicle during spermatogenesis, making it a marker for studying germ cell differentiation.
The protein is associated with acrosomal membranes and matrix in mature sperm, supporting studies of acrosome structure.
ACRV1 may be involved in sperm-zona binding or penetration, so it is relevant to studies of gamete interaction.
As a testis-specific differentiation antigen, ACRV1 can serve as a germline-restricted marker in male reproductive research.
ACRV1 is a testis-specific differentiation antigen that arises in the acrosomal vesicle during spermatogenesis and stays associated with acrosomal membranes and matrix in mature sperm. It may be involved in sperm-zona binding or penetration, though its exact mechanism is not defined in the sources.
ACRV1 stands for acrosomal vesicle protein 1. UniProt calls the protein acrosomal protein SP-10, and the aliases SP-10, SPACA2 and D11S4365 are also used. Alternatively spliced transcript variants of the gene have been described, so literature may refer to different transcripts.
A mouse ortholog, Acrv1, is recognised, which allows the protein's role in acrosome biology to be studied in mouse models. Check the datasheet of any product for its validated reactivity before choosing a species-specific reagent.
Other sperm acrosome proteins and fertilisation-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P26436; product specifications from Assay Genie datasheets.