HSF1
HSF1 (heat shock transcription factor 1, also known as HSTF1) is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements. It belongs to the heat shock factor family and has a reported role in the regulation of lifespan. Browse Assay Genie's current range of HSF1 research reagents below, or read on for the biology behind the target.
HSF1 is a transcription factor that is rapidly induced after temperature stress. It binds heat shock promoter elements (HSE), the DNA sequences that control heat shock gene expression. According to the NCBI Gene summary, the HSF1 protein plays a role in the regulation of lifespan, which has made it a point of interest in studies of stress responses and ageing.
Activity of HSF1 is controlled by phosphorylation. The NCBI Gene summary notes that phosphorylation represses its activity by promoting binding by heat shock protein 90. HSF1 is therefore studied alongside chaperone biology as well as transcriptional regulation.
UniProt records HSF1 in several compartments: the nucleus, including the nucleoplasm, and the cytoplasm, including the perinuclear region. It is also found at the spindle pole, the centrosome and the kinetochore at the centromere. The HSF1 gene is one of the heat shock transcription factor family genes, which also includes HSF2 and HSF4. Mouse has an ortholog, Hsf1.
HSF1 also has a role in microbial infection. In latent human immunodeficiency virus (HIV-1) infection, it contributes to transcriptional reactivation. It binds the HIV-1 long terminal repeat promoter (LTR) and recruits cellular transcriptional elongation factors, including CDK9, CCNT1 and EP300. The protein is also known as heat shock factor protein 1 and by the alias HSTF1.
HSF1 is induced rapidly after temperature stress and binds heat shock promoter elements, making it a central subject in stress-response research.
The NCBI Gene summary links HSF1 to the regulation of lifespan, supporting its use in studies of ageing biology.
Phosphorylation promotes heat shock protein 90 binding to HSF1 and represses its expression, which is relevant to studies of chaperone-transcription feedback.
HSF1 binds the HIV-1 LTR and recruits CDK9, CCNT1 and EP300 to reactivate latent viral transcription.
HSF1 is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). It plays a role in the regulation of lifespan. It also helps reactivate latent HIV-1 transcription by binding the viral LTR and recruiting elongation factors.
The HGNC-approved name is heat shock transcription factor 1, and UniProt lists the protein as heat shock factor protein 1. The alias HSTF1 is also used. HSF1 belongs to the heat shock transcription factor family, alongside HSF2 and HSF4.
According to the NCBI Gene summary, phosphorylation represses HSF1 by promoting binding by heat shock protein 90. A mouse ortholog, Hsf1, exists. Check the datasheet of any product for its validated reactivity.
Other members of the heat shock transcription factor family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q00613; product specifications from Assay Genie datasheets.