PTPRA
PTPRA (protein tyrosine phosphatase receptor type A) is a receptor-type tyrosine-protein phosphatase that contributes to integrin-mediated focal adhesion formation and Src family kinase activation. It is also known as LRP, HLPR, HPTPA, RPTPA, PTPRL2 and PTPA. Browse Assay Genie's current range of PTPRA research reagents below, or read on for the biology behind the target.
PTPRA is a tyrosine protein phosphatase involved in integrin-mediated focal adhesion formation. Following integrin engagement, it specifically recruits BCAR3, BCAR1 and CRK to focal adhesions. This promotes SRC-mediated phosphorylation of BCAR1 and the subsequent activation of PAK and the small GTPases RAC1 and CDC42. It has also been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signalling, cell adhesion and proliferation.
The protein belongs to the protein-tyrosine phosphatase family and to the receptor class 4 subfamily. Like other receptor-type PTPs, it has an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. UniProt records its location as the cell membrane and, within cell junctions, focal adhesions. The PTPRA gene is listed by HGNC in the group of receptor-type protein tyrosine phosphatases, and the mouse and rat orthologs are both named Ptpra.
Protein tyrosine phosphatases are signalling molecules that regulate cell growth, differentiation, the mitotic cycle and oncogenic transformation. RefSeq reports three alternatively spliced transcript variants of the PTPRA gene, which encode two distinct isoforms. Historical symbols such as LRP, HLPR, HPTPA, RPTPA, PTPRL2 and PTPA appear in older literature, so searching under several names helps when reviewing the PTPRA protein.
PTPRA acts after integrin engagement to recruit BCAR3, BCAR1 and CRK, making it a useful node for studying how adhesion signals are relayed.
Localised to focal adhesions, it is involved in their formation and is relevant to work on cell adhesion dynamics.
PTPRA dephosphorylates and activates Src family kinases, linking phosphatase activity to SRC-mediated signalling events.
As a receptor-type PTP implicated in adhesion and proliferation, it is relevant to studies of growth control and oncogenic transformation.
PTPRA is a receptor-type tyrosine phosphatase involved in integrin-mediated focal adhesion formation. After integrin engagement it recruits BCAR3, BCAR1 and CRK, promoting SRC-mediated phosphorylation of BCAR1 and activation of PAK, RAC1 and CDC42. It also dephosphorylates and activates Src family kinases.
PTPRA is also called LRP, HLPR, HPTPA, RPTPA, PTPRL2 and PTPA, and UniProt names it receptor-type tyrosine-protein phosphatase alpha. RefSeq describes three alternatively spliced variants of the gene that encode two distinct isoforms.
Yes, orthologs exist in rodents: both the mouse and the rat gene are named Ptpra. Cross-reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
Integrin signalling partners, Src pathway components and small GTPases linked to PTPRA function.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P18433; product specifications from Assay Genie datasheets.