P2RY14
P2RY14 (purinergic receptor P2Y14) is a G protein-coupled receptor for UDP-glucose and other UDP-sugars. It is also known as GPR105 and KIAA0001, and it belongs to the P2Y receptor group. Browse Assay Genie's current range of P2RY14 research reagents below, or read on for the biology behind the target.
P2RY14 acts as a receptor for UDP-glucose and other UDP-sugars, and it signals through coupled G-proteins. Its ligand preference sets it apart from other members of the P2Y family. It is not activated by ATP, ADP or UTP, so it responds to sugar-conjugated nucleotides rather than to the free nucleotides that activate many related receptors.
The P2RY14 gene encodes a protein of the G protein-coupled receptor 1 family, and the protein sits in the cell membrane. The P2Y receptors form a family with different pharmacological selectivity for various adenosine and uridine nucleotides, and P2Y14 is the subtype that recognises UDP-sugars. RefSeq reports two transcript variants for the gene, and both encode the same protein. Mouse and rat both carry a P2ry14 ortholog, which allows comparative work in rodent models.
The receptor has been implicated in extending the known immune system functions of P2Y receptors. It has been linked to regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Researchers studying P2RY14 therefore often work on purinergic signalling in immune and stem cell biology. Earlier names include G protein-coupled receptor 105 (GPR105) and KIAA0001. The HGNC name is purinergic receptor P2Y14, and the previous name was purinergic receptor P2Y, G-protein coupled, 14.
P2RY14 is a P2Y receptor that responds to UDP-glucose and other UDP-sugars, which makes it a distinct subtype for studying nucleotide-sugar signalling.
Its selectivity, with no activation by ATP, ADP or UTP, makes it a useful model for ligand specificity within the P2Y receptor group.
P2RY14 has been implicated in extending the known immune system functions of P2Y receptors.
The receptor has been linked to regulation of the stem cell compartment and may play a role in neuroimmune function.
P2RY14 is a G protein-coupled receptor on the cell membrane. It binds UDP-glucose and other UDP-sugars and signals through coupled G-proteins. It is not activated by ATP, ADP or UTP. It has been implicated in immune functions, regulation of the stem cell compartment and possibly neuroimmune function.
P2RY14 is also called GPR105 and KIAA0001. Previous names are G protein-coupled receptor 105 and purinergic receptor P2Y, G-protein coupled, 14. UniProt lists the protein as P2Y purinoceptor 14. Two transcript variants of the gene encode the same protein.
Yes. Mouse and rat each have an ortholog named P2ry14, so the receptor can be studied in rodent systems. Cross-species work should check the datasheet of any product for its validated reactivity.
Other P2Y receptors, purinergic signalling proteins and GPCR targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15391; product specifications from Assay Genie datasheets.