FITM1
FITM1 (fat storage inducing transmembrane protein 1, also known as FIT1) is an endoplasmic reticulum membrane protein that plays an important role in the formation of lipid droplets. It binds diacylglycerol and triacylglycerol, linking neutral lipid handling to cellular energy storage. Browse Assay Genie's current range of FITM1 research reagents below, or read on for the biology behind the target.
FITM1 plays an important role in the formation of lipid droplets (LDs), the storage organelles at the centre of lipid and energy homeostasis. UniProt annotates the protein as directly binding diacylglycerol (DAG) and triacylglycerol, the neutral lipids that make up the core of these organelles. Its localisation to the endoplasmic reticulum membrane is consistent with the ER being the site where lipid droplets originate.
The FITM1 protein is encoded by the human FITM1 gene and belongs to the FIT family, within the FIT1 subfamily. HGNC places it in the fat storage inducing transmembrane protein family. As the name indicates, it is a transmembrane protein. The mouse ortholog is Fitm1. Researchers looking at FITM1 may use an anti-FITM1 antibody or FITM1 ELISA kit to study its abundance and localisation, and the identifiers in the facts card help match reagents to the correct gene.
NCBI Gene summarises the predicted functions of FITM1 as diacylglycerol binding and triglyceride binding. It is predicted to be involved in fat cell differentiation, lipid droplet formation and the phospholipid biosynthetic process, and to be active in the endoplasmic reticulum membrane. These assignments are predictions, so experimental work remains important for defining how FITM1 contributes to lipid storage. The alias FIT1 is still widely used in the literature and in database records.
FITM1 plays an important role in lipid droplet formation, making it a relevant target for studying storage organelles in cells.
Lipid droplets sit at the centre of lipid and energy homeostasis, and FITM1 contributes to their formation.
FITM1 directly binds diacylglycerol and triacylglycerol, supporting research into how neutral lipids are recognised at the ER.
FITM1 is predicted to be involved in fat cell differentiation and phospholipid biosynthesis, which are areas open to further study.
FITM1 plays an important role in the formation of lipid droplets, which are storage organelles central to lipid and energy homeostasis. UniProt reports that it directly binds diacylglycerol and triacylglycerol. It is located in the endoplasmic reticulum membrane.
Yes. FIT1 is an alias for FITM1, whose HGNC name is fat storage inducing transmembrane protein 1. UniProt classes it in the FIT family, FIT1 subfamily. Both names may appear in publications, so searching with each is sensible.
Yes, the mouse ortholog is Fitm1. Orthology does not guarantee identical reagent reactivity, so check the datasheet of any product for its validated reactivity before using it with mouse samples.
Other lipid droplet, triglyceride synthesis and fat storage proteins that may be of interest alongside FITM1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt A5D6W6; product specifications from Assay Genie datasheets.