DGKZ
DGKZ (diacylglycerol kinase zeta, also known as DAGK5, hDGKzeta, DGK-ZETA and DAGK6) is a member of the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signalling cascades. Browse Assay Genie's current range of DGKZ research reagents below, or read on for the biology behind the target.
DGKZ belongs to the eukaryotic diacylglycerol kinase family. According to the RefSeq summary, the enzyme may attenuate protein kinase C activity by regulating diacylglycerol levels within intracellular signalling cascades and signal transduction. Because diacylglycerol is a signalling lipid that acts upstream of protein kinase C, control of its levels is a point at which this kinase can shape signal output. UniProt also notes that DGKZ does not regulate RASGRP1 activity, a useful distinction when interpreting diacylglycerol-dependent signalling experiments.
The DGKZ gene encodes a protein of the diacylglycerol kinase family with two assigned EC numbers, 2.7.1.107 and 2.7.1.93. UniProt records its subcellular locations as the nucleus, the cytosol, the cell membrane and the lamellipodium, a cell projection. This spread suggests the protein can act in more than one cellular compartment, which is relevant when designing localisation or fractionation studies. Alternative splicing occurs at this locus, and multiple transcript variants encoding distinct isoforms have been identified, so researchers working with a DGKZ antibody, DGKZ protein or DGKZ ELISA kit should consider which isoforms are relevant to their system.
HGNC places the gene in the ankyrin repeat domain containing group, the diacylglycerol kinase family and the group of microRNA protein coding host genes. Its previous name was diacylglycerol kinase, zeta 104kDa, and it has also appeared in the literature as DAGK5 and DAGK6. Orthologues are annotated in mouse and rat, both named Dgkz, which supports comparative work in rodent models.
DGKZ regulates diacylglycerol levels in intracellular signalling cascades, making it a focus for work on how signalling lipids are controlled.
DGKZ may attenuate protein kinase C activity, so it is studied in research on diacylglycerol-dependent kinase signalling.
DGKZ is annotated in the nucleus, cytosol, cell membrane and lamellipodium, which supports studies of compartment-specific lipid kinase function.
Alternative splicing at the DGKZ locus yields distinct isoforms, relevant to transcript variant and expression research.
DGKZ is a diacylglycerol kinase. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signalling cascades and signal transduction. UniProt also states that it does not regulate RASGRP1 activity. Check the datasheet of any product for its validated reactivity.
DGKZ is also called DAGK5, hDGKzeta, DGK-ZETA and DAGK6, and its previous HGNC name was diacylglycerol kinase, zeta 104kDa. Alternative splicing occurs at the locus, and multiple transcript variants encoding distinct isoforms have been identified.
Yes. Mouse and rat orthologues are both named Dgkz. The protein belongs to the eukaryotic diacylglycerol kinase family, which reflects conservation of this lipid kinase class across eukaryotes. Check the datasheet of any product for its validated reactivity.
Other diacylglycerol kinases and protein kinase C signalling partners with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13574; product specifications from Assay Genie datasheets.